Measurement of serum (1→3)-β-D-Glucan (BG) is an aid in the diagnosis of fungemia and
deep-seated mycoses, including invasive aspergillosis (IA). BG is present in the cell wall of …

Background Remdesivir improves clinical outcomes in patients hospitalized with moderate-to-severe
coronavirus disease 2019 (Covid-19). Whether the use of remdesivir in …

The repertoire of monoclonal antibodies and other biologic therapies targeted at precise
components of the immune response continues to expand rapidly. In theory, these therapies …

Patients treated with allogeneic hematopoietic cell transplantation (HCT) are at risk of
cytomegalovirus (CMV) reactivation and disease, which results in increased morbidity and mortality…

Background Remdesivir is an RNA polymerase inhibitor with potent antiviral activity in vitro
and efficacy in animal models of coronavirus disease 2019 (Covid-19). Methods We …

Importance Remdesivir demonstrated clinical benefit in a placebo-controlled trial in patients
with severe coronavirus disease 2019 (COVID-19), but its effect in patients with moderate …

Background Cytomegalovirus (CMV) infection remains a common complication after allogeneic
hematopoietic-cell transplantation. Letermovir is an antiviral drug that inhibits the CMV–…

Background Mucormycosis is an uncommon invasive fungal disease with high mortality and
few treatment options. Isavuconazole is a triazole active in vitro and in animal models …

Background In December 2003 and April 2005, signs and symptoms suggestive of infection
developed in two groups of recipients of solid-organ transplants. Each cluster was …

To the Editor: The Food and Drug Administration (FDA) approved voriconazole for the treatment
of invasive aspergillosis partly on the basis of data published in a report in the Journal, 1 …