This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics:
formation rate, pressure, flow, volume, turnover rate, composition, recycling and reabsorption. …

The receptor for advanced glycation end products (RAGE) is thought to be a primary
transporter of β-amyloid across the blood–brain barrier (BBB) into the brain from the systemic …

There is evidence that production and turnover of CSF help to clear toxic molecules such as
amyloid-β peptide (Aβ) from the interstitial‐fluid space of the brain to the bloodstream. Two …

Objective: To evaluate the production rate of CSF in patients with differing disease states.
Methods: The authors measured the production rate of CSF in three groups of patients: five …

Reduced clearance of amyloid β peptides (Aβ) across the blood-brain barrier contributes to
amyloid accumulation in Alzheimer disease. Amyloid β efflux transport is via the endothelial …

Microvascular accumulation and neuronal overproduction of amyloid-β peptide (Aβ) are
pathologic features of Alzheimer's disease (AD). In this study, we examined the receptor for …

Background. Heavy-charged-particle radiation has several advantages over protons and
photons for the treatment of intracranial lesions; it has an improved physical distribution of the …

Nine patients with atherosclerotic carotid artery disease associated with neck radiation were
compared to 40 control patients. The data suggest that significant differences in age, …

Background Age is the major risk factor for many neurodegenerative diseases, including
Alzheimer's disease (AD). There is an accumulation of amyloid-beta peptides (Aβ) in both the …

P-glycoprotein (P-gp), part of the blood-brain barrier, limits drug access to the brain and is
the target for therapies designed to improve drug penetration. P-gp also extrudes brain …