Recent studies indicate that mammals, including humans, maintain some capacity to renew
cardiomyocytes throughout postnatal life 1 , 2 . Yet, there is little or no significant cardiac …

PURPOSE We report the common characteristics of juvenile pilocytic astrocytomas revealed
by proton MR spectroscopy. METHODS Eight children with pilocytic astrocytomas were …

Some organisms, such as adult zebrafish and newborn mice, have the capacity to
regenerate heart tissue following injury. Unraveling the mechanisms of heart regeneration is …

Importance The use of sacubitril/valsartan is not endorsed by practice guidelines for use in
patients with New York Heart Association class IV heart failure with a reduced ejection …

Background : The oral vasopressin-2 receptor antagonist tolvaptan causes aquaresis in
patients with volume overload, potentially facilitating decongestion and improving the clinical …

Congestion is a primary reason for hospitalization in patients with acute heart failure (AHF).
Despite inpatient diuretics and vasodilators targeting decongestion, persistent congestion is …

Posttranslational modification of target substrates underlies biological processes through
activation/inactivation of signaling cascades. To concurrently identify the phosphoprotein …

Depressed sarcoplasmic reticulum (SR) Ca‐cycling is a hallmark of human and experimental
heart failure. Strategies to improve this impairment by either increasing SERCA2a levels or …

Background Continuous flow left ventricular assist devices have improved outcomes in patients
with end-stage heart failure that require mechanical circulatory support. Current devices …

Reactive gliosis is an invariant feature of the pathology of central nervous system (CNS)
injury and a major determinant of neuronal survival and regeneration. To begin to understand …