Primary angiitis of the CNS is histopathologically characterized by ischemic lesions and
small petechial hemorrhages. Unlike CT or conventional MR imaging, gradient-echo MR …

Parkinson’s disease (PD) is a complex, chronic, and progressive neurodegenerative disease
that is characterized by irreversible dopaminergic neuronal loss in the substantia nigra. …

Although α-synuclein (α-SYN) aggregation is a hallmark of sporadic and familial Parkinson's
disease (PD), it is not known how it contributes to early events of PD pathogenesis such as …

Short-hairpin RNA (shRNA)–mediated gene knockdown is a powerful tool for targeted gene
silencing and an emerging novel therapeutic strategy. Recent publications, however, …

Although Parkinson's disease is a movement disorder, in many patients cognitive dysfunction
is an important clinical sign. It is not yet clear whether this is attributable solely to a …

Alpha-synuclein phosphorylated at serine 129 (S129) is highly elevated in Parkinson's disease
patients where it mainly accumulates in the Lewy bodies. Several groups have studied …

Drug-induced dyskinesias in dopamine-denervated animals are known to depend on both
pre- and postsynaptic changes of the nigrostriatal circuitry. In lesion models used thus far, …

Preclinical efficacy of continuous delivery of 3,4-dihydroxyphenylalanine (DOPA) with adeno-associated
viral (AAV) vectors has recently been documented in animal models of …

We used a single adeno-associated viral (AAV) vector co-expressing tyrosine hydroxylase (TH)
and GTP cyclohydrolase 1 (GCH1) to investigate the relationship between vector dose …

A rare and unique form of familial parkinsonism with autosomal dominant inheritance that is
characterized by all cardinal features of parkinsonism, apathy, depression, central …