User profiles for Gürdal Şahin
Gurdal SahinLund University and Skåneuro Neurology Clinic Verified email at med.lu.se Cited by 881 |
Primary angiitis of the central nervous system and silent cortical hemorrhages
H Ay, G Şahin, I Saatci… - American journal of …, 2002 - Am Soc Neuroradiology
Primary angiitis of the CNS is histopathologically characterized by ischemic lesions and
small petechial hemorrhages. Unlike CT or conventional MR imaging, gradient-echo MR …
small petechial hemorrhages. Unlike CT or conventional MR imaging, gradient-echo MR …
[HTML][HTML] Neuroinflammation in parkinson's disease and its treatment opportunities
Parkinson’s disease (PD) is a complex, chronic, and progressive neurodegenerative disease
that is characterized by irreversible dopaminergic neuronal loss in the substantia nigra. …
that is characterized by irreversible dopaminergic neuronal loss in the substantia nigra. …
α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
Although α-synuclein (α-SYN) aggregation is a hallmark of sporadic and familial Parkinson's
disease (PD), it is not known how it contributes to early events of PD pathogenesis such as …
disease (PD), it is not known how it contributes to early events of PD pathogenesis such as …
[HTML][HTML] Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons
Short-hairpin RNA (shRNA)–mediated gene knockdown is a powerful tool for targeted gene
silencing and an emerging novel therapeutic strategy. Recent publications, however, …
silencing and an emerging novel therapeutic strategy. Recent publications, however, …
Functional convergence of dopaminergic and cholinergic input is critical for hippocampus-dependent working memory
LAB Wisman, G Sahin, M Maingay… - Journal of …, 2008 - Soc Neuroscience
Although Parkinson's disease is a movement disorder, in many patients cognitive dysfunction
is an important clinical sign. It is not yet clear whether this is attributable solely to a …
is an important clinical sign. It is not yet clear whether this is attributable solely to a …
Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease
Alpha-synuclein phosphorylated at serine 129 (S129) is highly elevated in Parkinson's disease
patients where it mainly accumulates in the Lewy bodies. Several groups have studied …
patients where it mainly accumulates in the Lewy bodies. Several groups have studied …
Presynaptic dopaminergic compartment determines the susceptibility to L-DOPA–induced dyskinesia in rats
Drug-induced dyskinesias in dopamine-denervated animals are known to depend on both
pre- and postsynaptic changes of the nigrostriatal circuitry. In lesion models used thus far, …
pre- and postsynaptic changes of the nigrostriatal circuitry. In lesion models used thus far, …
[HTML][HTML] Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease
Preclinical efficacy of continuous delivery of 3,4-dihydroxyphenylalanine (DOPA) with adeno-associated
viral (AAV) vectors has recently been documented in animal models of …
viral (AAV) vectors has recently been documented in animal models of …
[HTML][HTML] Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease
E Cederfjäll, N Nilsson, G Sahin, Y Chu, E Nikitidou… - Scientific reports, 2013 - nature.com
We used a single adeno-associated viral (AAV) vector co-expressing tyrosine hydroxylase (TH)
and GTP cyclohydrolase 1 (GCH1) to investigate the relationship between vector dose …
and GTP cyclohydrolase 1 (GCH1) to investigate the relationship between vector dose …
Familial parkinsonism with apathy, depression and central hypoventilation (Perry's syndrome)
…, T Kobayashi, FB Ataç, N Hattori, G Şahin… - Mapping the Progress of …, 2002 - Springer
A rare and unique form of familial parkinsonism with autosomal dominant inheritance that is
characterized by all cardinal features of parkinsonism, apathy, depression, central …
characterized by all cardinal features of parkinsonism, apathy, depression, central …