User profiles for G. Bruce Pike

Bruce Pike

CAIP Chair in Healthy Brain Aging, Head of Image Science, Professor - U of Calgary
Verified email at ucalgary.ca
Cited by 53836

MRI‐based myelin water imaging: a technical review

…, IR Levesque, GB Pike - Magnetic resonance in …, 2015 - Wiley Online Library
Multiexponential T 2 relaxation time measurement in the central nervous system shows a
component that originates from water trapped between the lipid bilayers of myelin. This myelin …

MRI of healthy brain aging: A review

ME MacDonald, GB Pike - NMR in Biomedicine, 2021 - Wiley Online Library
We present a review of the characterization of healthy brain aging using MRI with an emphasis
on morphology, lesions, and quantitative MR parameters. A scope review found 6612 …

Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template

…, AV Faria, A Mahmood, R Woods, AW Toga, GB Pike… - Neuroimage, 2008 - Elsevier
Brain registration to a stereotaxic atlas is an effective way to report anatomic locations of
interest and to perform anatomic quantification. However, existing stereotaxic atlases lack …

Promise and pitfalls of g-ratio estimation with MRI

…, M Boudreau, T Duval, J Cohen-Adad, GB Pike… - Neuroimage, 2018 - Elsevier
The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a myelinated
axon. It has a limited dynamic range in healthy white matter, as it is optimized for speed …

MRI simulation-based evaluation of image-processing and classification methods

RKS Kwan, AC Evans, GB Pike - IEEE transactions on medical …, 1999 - ieeexplore.ieee.org
With the increased interest in computer-aided image analysis methods, there is a greater
need for objective methods of algorithm evaluation. Validation of in vivo MRI studies is …

Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model

…, B Gill, GR Crelier, S Marrett, GB Pike - … in Medicine: An …, 1999 - Wiley Online Library
The relationship between blood oxygenation level‐dependent (BOLD) MRI signals, cerebral
blood flow (CBF), and oxygen consumption (CMR O2 ) in the physiological steady state was …

Identification of common variants associated with human hippocampal and intracranial volumes

…, MM Nöthen, RL Olvera, M Pandolfo, GB Pike… - Nature …, 2012 - nature.com
Identifying genetic variants influencing human brain structures may reveal new biological
mechanisms underlying cognition and neuropsychiatric illness. The volume of the …

Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex

…, B Gill, GR Crelier, S Marrett, GB Pike - Proceedings of the …, 1999 - National Acad Sciences
The aim of this study was to test the hypothesis that, within a specific cortical unit, fractional
changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen consumption (…

Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI

JG Sled, GB Pike - … Resonance in Medicine: An Official Journal …, 2001 - Wiley Online Library
We describe a novel imaging technique that yields all of the observable properties of the
binary spin‐bath model for magnetization transfer (MT) and demonstrate this method for in vivo …

Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer's disease …

…, M Albert, CG Lyketsos, R Woods, AW Toga, GB Pike… - Neuroimage, 2009 - Elsevier
The purpose of this paper is to establish single-participant white matter atlases based on
diffusion tensor imaging. As one of the applications of the atlas, automated brain segmentation …