Background Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR deletion
mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet …

We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

We leveraged IDH wild-type glioblastomas, derivative neurospheres, and single-cell gene
expression profiles to define three tumor-intrinsic transcriptional subtypes designated as …

While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human
cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors examined) harbors …

Glioblastoma (GBM) is the most common and aggressive primary brain tumor. To better
understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data from …

Immunotherapy is a promising area of therapy in patients with neuro-oncological malignancies.
However, early-phase studies show unique challenges associated with the assessment …

Glioblastoma is one of the most challenging forms of cancer to treat. Here we describe a
computational platform that integrates the analysis of copy number variations and somatic …

Glioblastomas, the most frequent and malignant of primary brain tumors, have a very poor
prognosis 1. Gene therapy of glioblastomas is limited by the short survival of viral vectors and …

The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …