Study Objectives: Obstructive sleep apnea (OSA) is the single most important preventable
medical cause of excessive daytime sleepiness (EDS) and driving accidents. OSA may also …

Intense immunosuppression followed by autologous haematopoietic stem-cell transplantation
has been assessed over the past few years as a possible new therapeutic strategy in …

Background Autologous hematopoietic stem cell transplantation has been used since 1996
for the treatment of severe autoimmune diseases refractory to approved therapies. We …

In multiple sclerosis (MS), dendritic cells (DCs) recruited to the central nervous system (CNS)
are thought to be involved in the regulation of autoimmune responses directed against …

To identify novel genes associated with ALS, we undertook two lines of investigation. We
carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls…

We studied the immunoregulatory features of murine mesenchymal stem cells (MSCs) in
vitro and in vivo. MSCs inhibited T-cell receptor (TCR)-dependent and -independent …

Objective The aim of this work was to evaluate whether the treatment effects on magnetic
resonance imaging (MRI) markers at the trial level were able to predict the treatment effects on …

The no evidence of disease activity (NEDA) composite measure has emerged as one attractive
new target of therapies in relapsing–remitting multiple sclerosis (RRMS), consisting of …

Objective: To summarize the evidence on immunoablative therapy followed by autologous
hematopoietic stem cell transplantation (aHSCT) to manage severe and treatment-refractory …

Hematopoietic stem cell transplantation (HSCT) has been proposed for the treatment of
severe multiple sclerosis (MS). In a phase 2 multicenter study we selected 19 non–primary …