Autoimmunity to antigens of the central nervous system is usually considered detrimental. T
cells specific to a central nervous system self antigen, such as myelin basic protein, can …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Partial injury to the spinal cord can propagate itself, sometimes leading to paralysis
attributable to degeneration of initially undamaged neurons. We demonstrated recently that …

Neurotrophins (NTs) promote neuronal survival and maintenance during development and
after injury. However, their role in the communication between the nervous system and the …

The limitation of immune responsiveness in the mammalian CNS has been attributed to the
intricate nature of neuronal networks, which would appear to be more susceptible than other …

Autoimmune T cells against central nervous system myelin associated peptide reduce the
spread of damage and promote recovery in injured rat spinal cord, findings that might lead to …

A recent study in our laboratory showed, against all expectations, that macrophages and a
particular type of T cell, by promoting regrowth and reducing the post-traumatic spread of …

The central nervous system (CNS), unlike the peripheral nervous system (PNS), is an
immune‐privileged site in which local immune responses are restricted. Whereas immune …

We recently demonstrated that autoimmune T cells protect neurons from secondary
degeneration after central nervous system (CNS) axotomy in rats. Here we show, using both …

The central nervous system (CNS) enjoys a unique relationship with the immune system.
Under non-pathological conditions, T cells move through the CNS but do not accumulate there. …