User profiles for H. Akutsu

Hiroki Akutsu

Associate Professor, Osaka University
Verified email at chem.sci.osaka-u.ac.jp
Cited by 3697

New trends in the synthesis of π-electron donors for molecular conductors and superconductors

J Yamada, H Akutsu, H Nishikawa, K Kikuchi - Chemical reviews, 2004 - ACS Publications
Research on the development of new molecularbased organic metals and superconductors
was stimulated by the first finding of metallic conductivity in a charge-transfer (CT) complex …

BioMagResBank

EL Ulrich, H Akutsu, JF Doreleijers… - Nucleic acids …, 2007 - academic.oup.com
… Our statistics show that many users have required 2 h or less to fill out an original deposition
to either the BMRB or PDB side of the system, and then required only an additional 15 min …

[PDF][PDF] A small-molecule inhibitor of Tgf-β signaling replaces Sox2 in reprogramming by inducing Nanog

…, FP Di Giorgio, K Koszka, D Huangfu, H Akutsu… - Cell stem cell, 2009 - cell.com
The combined activity of three transcription factors can reprogram adult cells into induced
pluripotent stem cells (iPSCs). However, the transgenic methods used for delivering …

Epigenetic instability in ES cells and cloned mice

D Humpherys, K Eggan, H Akutsu, K Hochedlinger… - science, 2001 - science.org
Cloning by nuclear transfer (NT) is an inefficient process in which most clones die before birth
and survivors often display growth abnormalities. In an effort to correlate gene expression …

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

M Stadtfeld, E Apostolou, H Akutsu, A Fukuda, P Follett… - Nature, 2010 - nature.com
… Amplified samples were normalized to 17 ng μl -1 and 1.5 μg of total cDNA was hybridized
to the arrays for 16 h at 45 C. Arrays were washed and scanned using the HT Array Plate …

Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation

K Eggan, H Akutsu, J Loring… - Proceedings of the …, 2001 - National Acad Sciences
To assess whether heterozygosity of the donor cell genome was a general parameter crucial
for long-term survival of cloned animals, we tested the ability of embryonic stem (ES) cells …

Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei

A Bortvin, K Eggan, H Skaletsky, H Akutsu, DL Berry… - 2003 - journals.biologists.com
The majority of cloned animals derived by nuclear transfer from somatic cell nuclei develop
to the blastocyst stage but die after implantation. Mouse embryos that lack an Oct4 gene, …

Age-associated alteration of gene expression patterns in mouse oocytes

…, G Falco, MG Carter, H Akutsu… - Human molecular …, 2004 - academic.oup.com
Decreasing oocyte competence with maternal aging is a major factor in human infertility. To
investigate the age-dependent molecular changes in a mouse model, we compared the …

Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei

D Humpherys, K Eggan, H Akutsu… - Proceedings of the …, 2002 - National Acad Sciences
To assess the extent of abnormal gene expression in clones, we assessed global gene
expression by microarray analysis on RNA from the placentas and livers of neonatal cloned mice …

[HTML][HTML] DNA methylation dynamics in human induced pluripotent stem cells over time

…, E Chikazawa, H Sakaguchi, H Akutsu… - PLoS …, 2011 - journals.plos.org
Epigenetic reprogramming is a critical event in the generation of induced pluripotent stem
cells (iPSCs). Here, we determined the DNA methylation profiles of 22 human iPSC lines …