The cellular thermal shift assay for evaluating drug target interactions in cells
R Jafari, H Almqvist, H Axelsson, M Ignatushchenko… - Nature protocols, 2014 - nature.com
… with blocking buffer for 1 h at room temperature or overnight at 4 C. (xi) Briefly rinse the
nitrocellulose membrane with wash buffer and incubate them for 1 h at room temperature with 15 …
nitrocellulose membrane with wash buffer and incubate them for 1 h at room temperature with 15 …
Negative CT angiography findings in patients with spontaneous subarachnoid hemorrhage: when is digital subtraction angiography still needed?
R Agid, T Andersson, H Almqvist… - American journal …, 2010 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: CTA is becoming the frontline modality to reveal aneurysms
in patients with SAH. However, in about 20% of SAH patients no aneurysm is found. In …
in patients with SAH. However, in about 20% of SAH patients no aneurysm is found. In …
Nervous system involvement in coronavirus disease 2019: results from a retrospective consecutive neuroimaging cohort
…, A Ahoromazdae, H Almqvist, Å Aspelin, H Martin… - Radiology, 2020 - pubs.rsna.org
… G, H, A new focus of leptomeningeal enhancement formed along the left inferior frontal gyrus
(arrow in H… G, H, A new focus of leptomeningeal enhancement formed along the left inferior …
(arrow in H… G, H, A new focus of leptomeningeal enhancement formed along the left inferior …
[HTML][HTML] CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
H Almqvist, H Axelsson, R Jafari, C Dan… - Nature …, 2016 - nature.com
… allowed to incubate at room temperature for 2 h before reading in an Envision plate reader
(… described above except that the bead incubation was performed at 2 h, 6 h and overnight. …
(… described above except that the bead incubation was performed at 2 h, 6 h and overnight. …
Muconic Acid Production Using Engineered Pseudomonas putida KT2440 and a Guaiacol-Rich Fraction Derived from Kraft Lignin
H Almqvist, H Veras, K Li… - ACS Sustainable …, 2021 - ACS Publications
Industrial lignin such as kraft lignin is an abundant feedstock for renewable chemicals and
materials. In this study, a process was developed for depolymerization of kraft lignin followed …
materials. In this study, a process was developed for depolymerization of kraft lignin followed …
Prediction of intracellular exposure bridges the gap between target-and cell-based drug discovery
…, GJ Wayne, H Almqvist, H Axelsson… - Proceedings of the …, 2017 - National Acad Sciences
… Dialysis was performed against HBSS at 37 C for 4 h; f u,cell was calculated as … Samples
from the receiver and donor sides were collected after 3 h, and permeability was calculated as …
from the receiver and donor sides were collected after 3 h, and permeability was calculated as …
[HTML][HTML] Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells
…, F Jeppsson, E Homan, H Almqvist, H Axelsson… - Nature …, 2018 - nature.com
… for 72 h and/or treated with DMSO/500 nM TH1579 for 24 h prior to harvesting by trypsinization.
For experiments with TH5427, cells were treated for 24 or 72 h with 10 µM compound. …
For experiments with TH5427, cells were treated for 24 or 72 h with 10 µM compound. …
Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis
…, C Sjöstrand, J Höijer, H Almqvist… - Journal of internal …, 2017 - Wiley Online Library
Background Imatinib, a tyrosine kinase inhibitor, has been shown to restore blood–brain
barrier integrity and reduce infarct size, haemorrhagic transformation and cerebral oedema in …
barrier integrity and reduce infarct size, haemorrhagic transformation and cerebral oedema in …
[HTML][HTML] Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization
…, T Seime, N Dias, M Lengquist, A Witasp, H Almqvist… - Atherosclerosis, 2019 - Elsevier
Background and aims Unstable carotid atherosclerosis causes stroke, but methods to identify
patients and lesions at risk are lacking. We recently found enrichment of genes associated …
patients and lesions at risk are lacking. We recently found enrichment of genes associated …
Saccharomyces cerevisiae: a potential host for carboxylic acid production from lignocellulosic feedstock?
AG Sandström, H Almqvist, D Portugal-Nunes… - Applied microbiology …, 2014 - Springer
Carboxylic acids are important bulk chemicals that can be used as building blocks for the
production of polymers, as acidulants, preservatives and flavour compound or as precursors for …
production of polymers, as acidulants, preservatives and flavour compound or as precursors for …