Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study

…, E Bollen, PW de Bruin, HAM Middelkoop… - Brain, 2008 - academic.oup.com
Atrophy is regarded a sensitive marker of neurodegenerative pathology. In addition to confirming
the well-known presence of decreased global grey matter and hippocampal volumes in …

Subjective sleep characteristics of 1,485 males and females aged 50–93: effects of sex and age, and factors related to self-evaluated quality of sleep

HAM Middelkoop… - The Journals of …, 1996 - academic.oup.com
Background . This epidemiologic study cross-sectionally examined the effects of sex and age
on subjective characteristics of sleep and the factors related to self-evaluated sleep quality …

[HTML][HTML] Vigilance: discussion of related concepts and proposal for a definition

…, GJ Lammers, R Fronczek, HAM Middelkoop… - Sleep Medicine, 2021 - Elsevier
We reviewed current definitions of vigilance to propose a definition, applicable in sleep
medicine. As previous definitions contained terms such as attention, alertness, and arousal, we …

45‐hour continuous quintuple‐site actimetry: relations between trunk and limb movements and effects of circadian sleep‐wake rhythmicity

HAM Middelkoop, EM Van Dam… - …, 1997 - Wiley Online Library
Diurnal and nocturnal trunk and limb motor activity of 20 healthy individuals was evaluated
by actimetry for 45 consecutive hours. Sleep was assessed by sleep logs. Overall, motor …

Assessment of cognition in Parkinson's disease

…, M Visser, NA Verwey, FRJ Verhey, HAM Middelkoop… - Neurology, 2003 - AAN Enterprises
Objective: To develop a short, practical instrument that is sensitive to the specific cognitive
deficits in Parkinson’s disease (PD) for comparing groups in research situations and for …

Cognitive impairment in Parkinson's disease

…, AM Stiggelbout, HAM Middelkoop… - Journal of Neurology …, 2007 - jnnp.bmj.com
Background: Cognitive impairment plays a role in Parkinson’s disease (PD) and has important
consequences for patient management. However, many aspects of cognitive impairment …

Structural brain changes in migraine

…, PAM Hofman, B van Lew, HAM Middelkoop… - Jama, 2012 - jamanetwork.com
Context A previous cross-sectional study showed an association of migraine with a higher
prevalence of magnetic resonance imaging (MRI)–measured ischemic lesions in the brain. …

Memory complaints in patients with normal cognition are associated with smaller hippocampal volumes

…, RGJ Westendorp, HAM Middelkoop - Journal of …, 2004 - Springer
We aimed to investigate volumetry of the medial temporal lobe in patients with subjective
memory complaints without any cognitive impairment. This study included 20 patients with …

EEG correlates in the spectrum of cognitive decline

…, MA Van Buchem, JG Van Dijk, HAM Middelkoop - Clinical …, 2007 - Elsevier
OBJECTIVE: To investigate relations between EEG measures and performance on tests of
global cognition, memory, language and executive functioning. METHODS: Twenty-two …

Progression of brain atrophy and cognitive decline in diabetes mellitus: a 3-year follow-up

…, GJ Blauw, JW Jukema, E Bollen, HAM Middelkoop… - Neurology, 2010 - AAN Enterprises
Objective: To investigate progression of MRI-assessed manifestations of cerebral degeneration
related to cognitive changes in a population of elderly patients with diabetes mellitus (DM…