User profiles for H.L. McConnell

Heather L. McConnell

Scientific Writer, Houston Methodist Hospital
Verified email at houstonmethodist.org
Cited by 856

The translational significance of the neurovascular unit

HL McConnell, CN Kersch, RL Woltjer… - Journal of biological …, 2017 - ASBMB
The mammalian brain is supplied with blood by specialized vasculature that is structurally
and functionally distinct from that of the periphery. A defining feature of this vasculature is a …

[HTML][HTML] Current and potential imaging applications of ferumoxytol for magnetic resonance imaging

…, AR Guimaraes, BE Hamilton, X Li, HL McConnell… - Kidney international, 2017 - Elsevier
Contrast-enhanced magnetic resonance imaging is a commonly used diagnostic tool.
Compared with standard gadolinium-based contrast agents, ferumoxytol (Feraheme, AMAG …

Cells of the blood–brain barrier: an overview of the neurovascular unit in health and disease

HL McConnell, A Mishra - The Blood-Brain Barrier: Methods and Protocols, 2022 - Springer
The brain is endowed with highly specialized vasculature that is both structurally and functionally
unique compared to vasculature supplying peripheral organs. The blood–brain barrier (…

Spatially mapped single-cell chromatin accessibility

…, FJ Steemers, W Zhang, HL McConnell… - Nature …, 2021 - nature.com
High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in complex
tissues, however, spatial orientation is lost. Here, we present single-cell combinatorial …

Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?

HL McConnell, Z Li, RL Woltjer, A Mishra - Neurochemistry international, 2019 - Elsevier
The neurovascular unit, consisting of neurons, astrocytes, and vascular cells, has become the
focus of much discussion in the last two decades and emerging literature now suggests an …

Ferumoxytol nanoparticle uptake in brain during acute neuroinflammation is cell-specific

HL McConnell, DL Schwartz, BE Richardson… - … , Biology and Medicine, 2016 - Elsevier
Ferumoxytol ultrasmall superparamagnetic iron oxide nanoparticles can enhance contrast
between neuroinflamed and normal-appearing brain tissue when used as a contrast agent for …

[HTML][HTML] Increased 20-HETE signaling suppresses capillary neurovascular coupling after ischemic stroke in regions beyond the infarct

Z Li, HL McConnell, TL Stackhouse, MM Pike… - Frontiers in Cellular …, 2021 - frontiersin.org
Neurovascular coupling, the process by which neuronal activity elicits increases in the local
blood supply, is impaired in stroke patients in brain regions outside the infarct. Such …

Combined iron oxide nanoparticle ferumoxytol and gadolinium contrast enhanced MRI define glioblastoma pseudoprogression

…, BE Hamilton, D Schwartz, HL McConnell… - Neuro …, 2019 - academic.oup.com
… This finding is consistent with prior preclinical observations by McConnell et al. Tissue
samples obtained from regions of only ferumoxytol enhancement demonstrated activated …

Effects of adding ruminal propionate on dry matter intake and glucose metabolism in steers fed a finishing ration

AR Rathert-Williams, HL McConnell… - Journal of Animal …, 2023 - academic.oup.com
The objective of this experiment was to determine if supplying additional propionate to the
rumen alters dry matter intake (DMI), feeding behavior, glucose metabolism, and rumen fluid …

Effect of concomitant 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor therapy on creatine phosphokinase levels and mortality among patients receiving …

HL McConnell, ET Perris, C Lowry, T Lodise… - Infectious diseases and …, 2014 - Springer
Introduction The prescribing information for daptomycin recommends discontinuing statin
therapy during receipt of daptomycin. The literature supporting this recommendation is sparse. …