Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course, neuroradiological
appearance of the lesions, involvement of susceptibility gene loci, and response to …

Multiple sclerosis (MS) is traditionally seen as an inflammatory demyelinating disease,
characterized by the formation of focal demyelinated plaques in the white matter of the central …

Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …

Microglia play a pivotal role in the maintenance of brain homeostasis but lose homeostatic
function during neurodegenerative disorders. We identified a specific apolipoprotein E (APOE)…

Some recent studies suggest that in progressive multiple sclerosis, neurodegeneration may
occur independently from inflammation. The aim of our study was to analyse the …

Devic’s disease [neuromyelitis optica (NMO)] is an idiopathic inflammatory demyelinating
disease of the CNS, characterized by attacks of optic neuritis and myelitis. The mechanisms …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo specimens,
different approaches must be undertaken to better understand disease pathogenesis and …

Brain-derived neurotrophic factor (BDNF) has potent effects on neuronal survival and plasticity
during development and after injury. In the nervous system, neurons are considered the …

Clonal composition and T cell receptor (TCR) repertoire of CD4 + and CD8 + T cells
infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with …

A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …