Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage: results of a prospective placebo-controlled double-blind trial
…, T Sasaki, K Takakura, I Nagata, H Kikuchi… - Journal of …, 1992 - thejns.org
✓ With the cooperation of 60 neurosurgical centers in Japan, a prospective randomized
placebo-controlled double-blind trial of a new calcium antagonist AT877 (hexahydro-1-(5-…
placebo-controlled double-blind trial of a new calcium antagonist AT877 (hexahydro-1-(5-…
Small unruptured intracranial aneurysm verification study: SUAVe study, Japan
M Sonobe, T Yamazaki, M Yonekura, H Kikuchi - Stroke, 2010 - Am Heart Assoc
Background and Purpose—The natural history and optimal management of incidentally
found small unruptured aneurysms <5 mm in size remain unclear. A prospective study was …
found small unruptured aneurysms <5 mm in size remain unclear. A prospective study was …
Treatment of moyamoya disease with STA-MCA anastomosis
J Karasawa, H Kikuchi, S Furuse, J Kawamura… - Journal of …, 1978 - thejns.org
✓ Moyamoya disease is a chronic occlusive cerebrovascular disease of unknown etiology
for which no effective treatment has been found. The authors report the results of 23 …
for which no effective treatment has been found. The authors report the results of 23 …
Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia
…, S Takami, I Nagata, H Kikuchi… - Proceedings of the …, 2001 - National Acad Sciences
Brain subjected to acute ischemic attack caused by an arterial blockage needs immediate
arterial recanalization. However, restoration of cerebral blood flow can cause tissue injury, …
arterial recanalization. However, restoration of cerebral blood flow can cause tissue injury, …
A surgical treatment of “moyamoya” disease “encephalo-myo synangiosis”
J KARASAWA, H KIKUCHI, S FURUSE… - Neurologia medico …, 1977 - jlc.jst.go.jp
An operation to place the temporal muscles on the brain surface, namely EncephaloMyo
Synangiosis, was carried out on 10 patients with “Moyamoya” disease lacking the middle …
Synangiosis, was carried out on 10 patients with “Moyamoya” disease lacking the middle …
Prevention of rat cerebral aneurysm formation by inhibition of nitric oxide synthase
…, I Nagata, K Nozaki, S Kondo, M Kurino, H Kikuchi - Circulation, 2000 - Am Heart Assoc
Background—Cerebral saccular aneurysm is a major cause of subarachnoid hemorrhage,
one of the cerebrovascular diseases with the highest mortality. The mechanisms underlying …
one of the cerebrovascular diseases with the highest mortality. The mechanisms underlying …
Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage
…, K Takakura, H Abe, T Yoshimoto, H Kikuchi… - …, 1998 - journals.lww.com
OBJECTIVE: The effect of ebselen, a seleno-organic compound with antioxidant activity
through a glutathione peroxidase-like action, on the outcome of subarachnoid hemorrhage was …
through a glutathione peroxidase-like action, on the outcome of subarachnoid hemorrhage was …
Long-term follow-up study after extracranial-intracranial bypass surgery for anterior circulation ischemia in childhood moyamoya disease
…, H Touho, H Ohnishi, S Miyamoto, H Kikuchi - Journal of …, 1992 - thejns.org
✓ Between May, 1974, and March, 1991, 104 patients with moyamoya disease, all under 16
years old at the time of first surgery, underwent superficial temporal-to-middle cerebral …
years old at the time of first surgery, underwent superficial temporal-to-middle cerebral …
Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons
…, D Nakatsuka, Y Watanabe, I Nagata, H Kikuchi… - Neuroscience …, 2000 - Elsevier
Oxidative stress is implicated in the pathogenesis of neuronal degenerative diseases. Oxidative
stress has been shown to activate extracellular signal-regulated kinases (ERK)1/2. We …
stress has been shown to activate extracellular signal-regulated kinases (ERK)1/2. We …
Results of microsurgical treatment for intramedullary spinal cord ependymomas: analysis of 36 cases
M Hoshimaru, T Koyama, N Hashimoto, H Kikuchi - Neurosurgery, 1999 - journals.lww.com
OBJECTIVE: Although intramedullary spinal cord ependymomas are amenable to surgical
total resection, some ependymomas have been associated with severe surgical morbidity. …
total resection, some ependymomas have been associated with severe surgical morbidity. …