The complement-derived anaphylatoxin, C5a, is a potent phlogistic molecule that mediates
its effects by binding to C5a receptor (C5aR; CD88). We now demonstrate specific binding of …

The role of endogenous NO in the regulation of acute lung injury is not well defined. We
investigated the effects of inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) …

Estrogen has been implicated in the observed female bias in autoimmune diseases. However,
the mechanisms behind this gender dimorphism are poorly defined. We have previously …

Matrix metalloproteinases (MMPs) have been implicated in the tissue injury seen in
neutrophil-dependent models of acute lung injury. However, the role of MMPs in macrophage-…

Objectives To determine whether rabbit cartilage can be tissue engineered using a polyglycolic
acid (PGA) construct composed of PGA mesh, autologous chondrocytes, and alginate …

Objectives To design and develop a biodegradable tracheal stent that can be used internally
to stabilize and support surgically reconstructed airways. Design In vitro mechanical and …

A new model for rabbit corneal vascularization, created by making a penetrating wound in
corneas with epithelium of conjunctival origin, is described. Obligate resurfacing of the cornea …

Monocyte chemotactic protein-3 (MCP-3/CCL7) has potent eosinophil chemoattractant
properties. The present study determined its relative contribution to the formation of Th2 cytokine-…

Vascular endothelial cells are key participants in the development of inflammatory-mediated
tissue injury. Not all tissues have the same response to inflammation and the role of …

Objectives/Hypothesis To design and develop an e‐ternal biodegradable tracheal stent for
use in airway reconstructive surgery. Study Design E‐perimental model. Methods …