Objective: To compare brain β-amyloid (Aβ) burden measured with [ 11 C]Pittsburgh Compound
B (PIB) PET in normal aging, Alzheimer disease (AD), and other dementias. Methods: …

The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the
worldwide Alzheimer's Disease Neuroimaging Initiative (ADNI), recruited 1112 participants …

Amyloid imaging with 18 F-labeled radiotracers will allow widespread use, facilitating research,
diagnosis, and therapeutic development for Alzheimer disease. The purpose of the study …

Regional cerebral blood flow (rCBF) was measured with PET in seven healthy subjects
while they carried out a mental rotation task in which they decided whether alphanumeric …

Approximately 30% of healthy persons aged over 75 years show Aβ deposition at autopsy.
It is postulated that this represents preclinical Alzheimer's disease (AD). We evaluated the …

Objective Biomarkers for Alzheimer disease (AD) can detect the disease pathology in
asymptomatic subjects and individuals with mild cognitive impairment (MCI), but their cognitive …

Amyloid-β (Aβ) imaging with N-methyl- 11 C-2-(4′-methylamino-phenyl)-6-hydroxy-benzothiazole
( 11 C-6-OH-BTA-1; also known as 11 C-PIB) shows a robust increase in cortical …

Background Amyloid-β (Aβ) plaque formation is a hallmark of Alzheimer's disease (AD) and
precedes the onset of dementia. Aβ imaging should allow earlier diagnosis, but clinical …

Purpose Amyloid imaging with 18 F-labelled radiotracers will allow widespread use of this
technique, facilitating research, diagnosis and therapeutic development for Alzheimer’s …

In ischaemic stroke, expansion of the infarct core occurs at the expense of surrounding
hypoxic, metabolically compromised tissue over a period of 24 h or more in a considerable …