The initial mechanical tissue disruption of spinal cord injury (SCI) is followed by a period of
secondary injury that increases the size of the lesion. The secondary injury has long been …

Current treatments for acute spinal cord injury are based on animal models of human spinal
cord injury (SCI). These models have shown that the initial traumatic injury to cord tissue is …

Behavioral assessment after spinal cord contusion has long focused on open field locomotion
using modifications of a rating scale developed by Tarlov and Klinger (1954). However, on…

… The Basso, Beattie, and Bresnahan (BBB) scale was developed by assessing recovery
patterns in a large number of rats which sustained mild or moderate injuries of the cord using a …

Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit
development and experience-dependent plasticity. Although glia are affected by activity and …

… Bresnahan, JC An electron microscopic analysis of axonal alterations following blunt
contusion of the spinal cord of the rhesus monkey (Macaca mulatta). /. Neurol. Sci. …

Primates are an important and unique animal resource. We have developed a nonhuman
primate model of spinal cord injury (SCI) to expand our knowledge of normal primate motor …

The Multicenter Animal Spinal Cord Injury Study (MASCIS) adopted a modified 21-point
open field locomotor scale developed by Basso, Beattie, and Bresnahan (BBB) at Ohio State …

The neurotrophin receptor p75 is induced by various injuries to the nervous system, but its
role after injury has remained unclear. Here, we report that p75 is required for the death of …

Contusion injuries of the rat thoracic spinal cord were made using a standardized device
developed for the Multicenter Animal Spinal Cord Injury Study (MASCIS). Lesions of different …