Brain aging research relies mostly on cross-sectional studies, which infer true changes from
age differences. We present longitudinal measures of five-year change in the regional brain …

In a prospective cross-sectional study, we used computerized volumetry of magnetic
resonance images to examine the patterns of brain aging in 148 healthy volunteers. The most …

We examined age-, sex-, and hemisphere-related differences in the cerebral cortex. Volumes
of the cerebral hemispheres and 13 regions of interest (ROIs) were measured on magnetic …

… Their MRI scans were examined by an experienced neuroradiologist (JD Acker) for signs
of space-occupying lesions and cerebrovascular abnormalities, and only the participants …

Objective: To test the hypothesis that entorhinal cortex (EC) volume decreases at a slower
rate than the hippocampal (HC) volume in healthy adults, and to examine whether the rate of …

Article abstract—We examined the pattern of neuroanatomic abnormalities in adults with
Down's syndrome (DS) and the cognitive correlates of these abnormalities. Specifically, we …

Untreated hypertension negatively affects brain anatomy and cognitive functions, but the
effects of medically treated hypertension are unclear. The authors compared 40 middle-age …

We reviewed postmortem and neuroimaging studies of striatal neuroanatomy in humans.
The quantitative review revealed evidence of moderate age-related shrinkage of the caudate …

BACKGROUND AND PURPOSE: Information about age-related changes in the striatum
comes almost exclusively from cross-sectional studies. We examined age-related differences …

Introduction The integration of behavioral health services in primary care settings presents
an opportunity to enhance the delivery of tobacco cessation interventions in the primary care …