Abnormal aggregates of the synaptic protein, α-synuclein, are the dominant pathology in
syndromes known as the synucleinopathies. The cellular aggregation of the protein occurs in …

Neuropathological changes in Parkinson's disease progress slowly and spread according to
a characteristic pattern. Recent papers have shed light on this progression of pathology by …

… Professor Revesz and Dr Holton are supported by the Alzheimer's Research UK, the
Progressive Supranuclear Palsy (Europe) Association and Brain Net Europe. Professor Lees and …

Two subjects with Parkinson's disease who had long-term survival of transplanted fetal
mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy …

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been shown to cause
autosomal dominant Parkinson's disease. Few mutations in this gene have been identified. We …

The clinical diagnosis of progressive supranuclear palsy (PSP) relies on the identification of
characteristic signs and symptoms. A proportion of pathologically diagnosed cases do not …

The relative importance of Lewy- and Alzheimer-type pathologies to dementia in Parkinson's
disease remains unclear. We have examined the combined associations of α-synuclein, tau …

We have carried out a systematic review of the case files of 242 donors with pathologically
verified Parkinson's disease at the Queen Square Brain Bank for Neurological Disorders in an …

Multiple system atrophy (MSA) has varying clinical (MSA-P versus MSA-C) and pathological
[striatonigral degeneration (SND) versus olivopontocerebellar atrophy (OPCA)] phenotypes. …

We report a British family with young-onset Parkinson’s disease (PD) and a G51D SNCA
mutation that segregates with the disease. Family history was consistent with autosomal …