[HTML][HTML] Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA
…, J Berman, C Betts, A Blocker, J Bredno… - Annals of …, 2020 - Elsevier
Background Early cancer detection could identify tumors at a time when outcomes are
superior and treatment is less morbid. This prospective case-control sub-study (from …
superior and treatment is less morbid. This prospective case-control sub-study (from …
[HTML][HTML] Circulating tumor DNA allele fraction: a candidate biological signal for multicancer early detection tests to assess the clinical significance of cancers
J Bredno, O Venn, X Chen, P Freese… - The American Journal of …, 2022 - Elsevier
Current imaging-based cancer screening approaches provide useful but limited prognostic
information. Complementary to existing screening tests, cell-free DNA–based multicancer …
information. Complementary to existing screening tests, cell-free DNA–based multicancer …
Blood-brain barrier permeability assessed by perfusion CT predicts symptomatic hemorrhagic transformation and malignant edema in acute ischemic stroke
…, T Schneider, SC Cheng, J Bredno… - American journal …, 2011 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: SHT and ME are feared complications in patients with
acute ischemic stroke. They occur >10 times more frequently in tPA-treated versus placebo-…
acute ischemic stroke. They occur >10 times more frequently in tPA-treated versus placebo-…
Quality of DICOM header information for image categorization
…, H Schubert, BB Wein, J Bredno… - … 2002: PACS and …, 2002 - spiedigitallibrary.org
The widely used DICOM 3.0 imaging protocol specifies optional tags to store specific
information on modality and body region within the header: Body Part Examined and Anatomic …
information on modality and body region within the header: Body Part Examined and Anatomic …
Reperfusion is a more accurate predictor of follow-up infarct volume than recanalization: a proof of concept using CT in acute ischemic stroke patients
Background and Purpose— The purpose of this study was to compare recanalization and
reperfusion in terms of their predictive value for imaging outcomes (follow-up infarct volume, …
reperfusion in terms of their predictive value for imaging outcomes (follow-up infarct volume, …
[HTML][HTML] A DNA methylation atlas of normal human cell types
… We then constructed reference atlas A with 1,232 regions (top 25 markers per cell type), in
which the A i,j cell holds the U proportion of the ith marker in the jth cell type. Given an input …
which the A i,j cell holds the U proportion of the ith marker in the jth cell type. Given an input …
[HTML][HTML] High and low molecular weight fluorescein isothiocyanate (FITC)–dextrans to assess blood-brain barrier disruption: Technical considerations
A Hoffmann, J Bredno, M Wendland, N Derugin… - Translational stroke …, 2011 - Springer
This note is to report how histological preparation techniques influence the extravasation
pattern of the different molecular sizes of fluorescein isothiocyanate (FITC)–dextrans, typically …
pattern of the different molecular sizes of fluorescein isothiocyanate (FITC)–dextrans, typically …
Content-based image retrieval in medical applications: a novel multistep approach
…, BB Wein, J Dahmen, J Bredno… - … and Retrieval for …, 1999 - spiedigitallibrary.org
In the past few years, immense improvement was obtained in the field of content-based image
retrieval. Nevertheless, existing systems still fail when applied to medical image databases…
retrieval. Nevertheless, existing systems still fail when applied to medical image databases…
[HTML][HTML] Clinical correlates of circulating cell-free DNA tumor fraction
J Bredno, J Lipson, O Venn, AM Aravanis, A Jamshidi - PLoS One, 2021 - journals.plos.org
Background Oncology applications of cell-free DNA analysis are often limited by the amount
of circulating tumor DNA and the fraction of cell-free DNA derived from tumor cells in a …
of circulating tumor DNA and the fraction of cell-free DNA derived from tumor cells in a …
Intertumoral Heterogeneity of CD3+ and CD8+ T-Cell Densities in the Microenvironment of DNA Mismatch-Repair–Deficient Colon Cancers: Implications for …
…, J Bredno, F Ough, A Djalilvand, J Clements… - Clinical Cancer …, 2019 - AACR
… J. Bredno is an employee of Roche Tissue Diagnostics, and holds ownership interest (including
patents) in Roche Holding AG. FM Ough is an employee of and holds ownership interest …
patents) in Roche Holding AG. FM Ough is an employee of and holds ownership interest …