User profiles for J. Fernandez-Ruiz

Javier Fernández-Ruiz

Profesor de Bioquímica, Universidad Complutense
Verified email at ucm.es
Cited by 21059

Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism

…, M Hesse, J Fernández-Ruiz… - Antioxidants & redox …, 2011 - liebertpub.com
… 9 Innamorato NGJazwa ARojo AIGarcía CFernández-Ruiz JGrochot-Przeczek AStachurska
AJozkowicz ADulak JCuadrado ADifferent susceptibility to the Parkinson's toxin MPTP in …

Pharmacological and biochemical interactions between opioids and cannabinoids

…, J Corchero, J Romero, JJ Fernández-Ruiz… - Trends in …, 1999 - cell.com
Opioids and cannabinoids are among the most widely consumed drugs of abuse in humans.
A number of studies have shown that both types of drugs share several pharmacological …

Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders

…, MR Cilio, H Cross, J FernandezRuiz, J French… - …, 2014 - Wiley Online Library
To present a summary of current scientific evidence about the cannabinoid, cannabidiol (
CBD ) with regard to its relevance to epilepsy and other selected neuropsychiatric disorders. …

Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease

…, JA Ramos, R Mechoulam, J Fernández-Ruiz - Neurobiology of …, 2005 - Elsevier
Cannabinoids have been reported to provide neuroprotection in acute and chronic
neurodegeneration. In this study, we examined whether they are also effective against the toxicity …

[HTML][HTML] Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration

…, M Jendrach, M García-Arencíbia, J Fernández-Ruiz… - PloS one, 2009 - journals.plos.org
Background Parkinson's disease (PD) is an adult-onset movement disorder of largely unknown
etiology. We have previously shown that loss-of-function mutations of the mitochondrial …

The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors

…, J Fernández-Ruiz, J Romero, J Martinez-Orgado - Neurobiology of …, 2010 - Elsevier
To investigate the mechanisms involved in cannabidiol (CBD)-induced neuroprotection in
hypoxic–ischemic (HI) immature brain, forebrain slices from newborn mice underwent oxygen …

Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent …

…, JA Ramos, R Mechoulam, J Fernández-Ruiz - Brain research, 2007 - Elsevier
We have recently demonstrated that two plant-derived cannabinoids, Δ 9 -tetrahydrocannabinol
and cannabidiol (CBD), are neuroprotective in an animal model of Parkinson's disease (…

Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine

S González, MG Cascio, J Fernández-Ruiz, F Fezza… - Brain research, 2002 - Elsevier
Despite recent data suggesting that the endocannabinoid transmission is a component of
the brain reward system and plays a role in dependence/withdrawal to different habit-forming …

The endogenous cannabinoid system and brain development

J Fernández-Ruiz, F Berrendero, ML Hernández… - Trends in …, 2000 - cell.com
Cannabinoid receptors and their endogenous ligands constitute a novel modulatory system
that is involved in specific brain functions, such as nociception, control of movement, …

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

J FernándezRuiz, O Sagredo… - British journal of …, 2013 - Wiley Online Library
Cannabidiol (CBD) is a phytocannabinoid with therapeutic properties for numerous disorders
exerted through molecular mechanisms that are yet to be completely identified. CBD acts …