SPOTLIGHT Critical review thesis. Like SREBP-1a, SREBP-2 has a long transcriptional
activation domain, but it preferentially activates cholesterol synthesis (1). SREBP-1a and SREBP-…

2 GOLDSTEIN ET AL depended on the sequential cell surface binding, internalization, and …
low density lipoprotein (LDL)(Goldstein & Brown 1974, Goldstein et aI1976). This uptake …

The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions,
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback …

This thoroughly revised and updated Fourth Edition of a time-honored text provides the
reader with a comprehensive introduction to the field of scanning electron microscopy (SEM), …

Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Beyond the Best Interests of the Child is the first volume in a classic trilogy of works by Joseph
Goldstein, former Sterling Professor Emeritus of Law at Yale Law School; Albert J. Solnit, …

we studied copolymer 1 (Copaxone) in a multicenter (11-university) phase III trial of patients
with relapsing-remitting multiple sclerosis (MS). Two hundred fifty-one patients were …

Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently,
in response to oncogenic stimuli, including genotoxic stress. We modified the use of …

The Unified Huntington's Disease Rating Scale (UHDRS) was developed as a clinical rating
scale to assess four domains of clinical performance and capacity in HD: motor function, …