Malignant brain tumours continue to be the cause of a disproportionate level of morbidity
and mortality across a wide range of individuals. The most common variants in the adult and …

Diffuse gliomas such as astrocytomas and oligodendrogliomas are the most common form
of intrinsic brain tumor in adults. Even within a single pathologic class, these tumors are both …

Over the last decade, developments in molecular profiling have radically altered the diagnosis,
classification, and management of numerous cancer types, with primary brain tumors …

Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic
glioma driving alterations and suboptimal disease classification. We defined the complete …

Glioblastoma multiforme (GBM) comprises several molecular subtypes, including proneural
GBM. Most therapeutic approaches targeting glioma cells have failed. An alternative strategy …

Background The prediction of clinical behavior, response to therapy, and outcome of infiltrative
glioma is challenging. On the basis of previous studies of tumor biology, we defined five …

Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood. …

Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate the
brain die of unknown causes. Here, we identify plasmin from the reactive brain stroma as a …

In normal brain, the side population (SP) phenotype is generated by ABC transporter activity
and identifies stem cell and endothelial cell subpopulations by dye exclusion. By drug efflux…

… 5D–J). This effect notably exceeded the more modest (∼50%) reduction in PTEN … (J)
Quantification of PTEN immunostaining for two tumors in each genotype (see the Materials and …