Forward osmosis (FO) has been increasingly studied in the past decade for its potential as
an emerging low-energy water and wastewater treatment process. However, the term “low-…

As the advent of next-generation sequencing (NGS) technology, various de novo assembly
algorithms based on the de Bruijn graph have been developed to construct chromosome-…

Neurons within the central nervous system receive humoral and central (neurotransmitter or
neuropeptide) signals that ultimately regulate ingestive behavior and metabolism. Recent …

Background Among breast cancers without human epidermal growth factor receptor 2 (HER2)
amplification, overexpression, or both, a large proportion express low levels of HER2 that …

Acquisition of the intestinal microbiota begins at birth, and a stable microbial community
develops from a succession of key organisms. Disruption of the microbiota during maturation by …

ContextMicroRNAs have potential as diagnostic biomarkers and therapeutic targets in
cancer. No study has evaluated the association between microRNA expression patterns and …

Background Trastuzumab deruxtecan (DS-8201) is an antibody-drug conjugate composed
of an anti-HER2 (human epidermal growth factor receptor 2) antibody, a cleavable …

Purpose Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, demonstrated efficacy as
monotherapy and in combination with fulvestrant in women with hormone receptor (HR)–…

Background The anti-HER2 monoclonal antibody trastuzumab and the tyrosine kinase inhibitor
lapatinib have complementary mechanisms of action and synergistic antitumour activity …

Background AKT pathway activation is implicated in endocrine-therapy resistance. Data on
the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, …