Owing to the common coincidence of osteoporosis and vascular disease, pathophysiological
links between both disorders have long been sought. The osteoprotegerin (OPG)/receptor …

Background The ability to mount a prominent inflammatory response to bacterial pathogens
confers an advantage in innate immune defense but may signal an increased risk of …

OBJECTIVE Carotid intima-media thickness (CIMT) is a marker of subclinical organ damage
and predicts cardiovascular disease (CVD) events in the general population. It has also …

… Willeit was supported by a scholarship from the Dr Johannes and Hertha Tuba Foundation.
Dr Kronenberg was supported by a grant from the Competence Centers for Excellent …

Rationale: MicroRNAs (miRNAs) have been implicated in the epigenetic regulation of key
metabolic, inflammatory, and antiangiogenic pathways in type 2 diabetes (DM) and may …

Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …

Background Recently, the International Parkinson and Movement Disorder Society has
defined research criteria for prodromal Parkinson's disease (PD), but to date their predictive …

The prevalence of insulin resistance in the most common metabolic disorders is still an
undefined issue. We assessed the prevalence rates of insulin resistance in subjects with …

Background—Chronic infections have been implicated in the pathogenesis of atherosclerosis,
yet from an epidemiological perspective, this concept remains controversial. Methods and …

Background— Osteoprotegerin is a novel member of the tumor necrosis factor receptor
superfamily and a soluble decoy receptor of the receptor activator of nuclear factor-κB ligand. …