User profiles for J.A. Helpern

Joseph A. Helpern

New Vision Research
Verified email at musc.edu
Cited by 19198

Diffusional kurtosis imaging: the quantification of non‐gaussian water diffusion by means of magnetic resonance imaging

JH Jensen, JA Helpern, A Ramani, H Lu… - … in Medicine: An …, 2005 - Wiley Online Library
… In particular, we find sharp differences between the diffusional kurtosis in white and gray
matter, confirming the preliminary results reported by Jensen and Helpern (2). We believe that …

MRI quantification of non‐Gaussian water diffusion by kurtosis analysis

JH Jensen, JA Helpern - NMR in Biomedicine, 2010 - Wiley Online Library
Quantification of non‐Gaussianity for water diffusion in brain by means of diffusional kurtosis
imaging (DKI) is reviewed. Diffusional non‐Gaussianity is a consequence of tissue structure …

White matter characterization with diffusional kurtosis imaging

E Fieremans, JH Jensen, JA Helpern - Neuroimage, 2011 - Elsevier
Diffusional kurtosis imaging (DKI) is a clinically feasible extension of diffusion tensor
imaging that probes restricted water diffusion in biological tissues using magnetic resonance …

Estimation of tensors and tensor‐derived measures in diffusional kurtosis imaging

…, JH Jensen, BA Ardekani, JA Helpern - Magnetic resonance in …, 2011 - Wiley Online Library
This article presents two related advancements to the diffusional kurtosis imaging estimation
framework to increase its robustness to noise, motion, and imaging artifacts. The first …

Three‐dimensional characterization of non‐gaussian water diffusion in humans using diffusion kurtosis imaging

…, JH Jensen, A Ramani, JA Helpern - NMR in Biomedicine: An …, 2006 - Wiley Online Library
Conventional diffusion tensor imaging (DTI) measures water diffusion parameters based on
the assumption that the spin displacement distribution is a Gaussian function. However, …

Assessment of relative brain iron concentrations using T2‐weighted and T2*‐weighted MRI at 3 Tesla

…, JC Deniau, RA Knight, JA Helpern - Magnetic resonance …, 1994 - Wiley Online Library
In this paper a new method is presented for the relative assessment of brain iron concentrations
based on the evaluation of T 2 and T 2 * ‐weighted images. A multiecho sequence is …

Increased iron‐related MRI contrast in the substantia nigra in Parkinson's disease

…, GG Brown, JC Deniau, NM Buderer, JA Helpern - Neurology, 1995 - AAN Enterprises
Article abstract—Elevated iron levels in the substantia nigra (SN) of the brain in Parkinson's
disease (PD) may mediate lipid peroxidative reactions, promoting SN neuronal death. To …

Low brain magnesium in migraine

…, A Vande‐Linde, SR Levine, JA Helpern… - … : The Journal of …, 1989 - Wiley Online Library
Brain magnesium was measured in migraine patients and control subjects using in vivo 31‐PhosphorusNuclear
Magnetic Resonance Spectroscopy, pMg and pH were calculated from …

Revealing mesoscopic structural universality with diffusion

DS Novikov, JH Jensen, JA Helpern… - Proceedings of the …, 2014 - National Acad Sciences
Measuring molecular diffusion is widely used for characterizing materials and living organisms
noninvasively. This characterization relies on relations between macroscopic diffusion …

Correction of motional artifacts in diffusion-weighted MR images using navigator echoes

RJ Ordidge, JA Helpern, ZX Qing, RA Knight… - Magnetic resonance …, 1994 - Elsevier
Patient motion can seriously degrade the quality of diffusion-weighted MR images obtained
using standard 2DFT imaging procedures. The main source of error arises from an MR …