User profiles for J.G. Sled

John G. Sled

Senior Scientist, Hospital for Sick Children / Professor, University of Toronto
Verified email at utoronto.ca
Cited by 21007

[HTML][HTML] Modelling and interpretation of magnetization transfer imaging in the brain

JG Sled - Neuroimage, 2018 - Elsevier
Magnetization transfer contrast has yielded insight into brain tissue microstructure changes
across the lifespan and in a range of disorders. This progress has been aided by the …

A nonparametric method for automatic correction of intensity nonuniformity in MRI data

JG Sled, AP Zijdenbos, AC Evans - IEEE transactions on …, 1998 - ieeexplore.ieee.org
A novel approach to correcting for intensity nonuniformity in magnetic resonance (MR) data
is described that achieves high performance without requiring a model of the tissue classes …

Design and construction of a realistic digital brain phantom

…, AP Zijdenbos, V Kollokian, JG Sled… - IEEE transactions on …, 1998 - ieeexplore.ieee.org
After conception and implementation of any new medical image processing algorithm,
validation is an important step to ensure that the procedure fulfils all requirements set forth at the …

[PDF][PDF] Behavioral phenotypes of Disc1 missense mutations in mice

…, T Shiroishi, MD Houslay, RM Henkelman, JG Sled… - Neuron, 2007 - cell.com
To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two
independently derived ENU-induced mutations in Exon 2 of mouse Disc1. Mice with …

Quantitative imaging of magnetization transfer exchange and relaxation properties in vivo using MRI

JG Sled, GB Pike - … Resonance in Medicine: An Official Journal …, 2001 - Wiley Online Library
We describe a novel imaging technique that yields all of the observable properties of the
binary spin‐bath model for magnetization transfer (MT) and demonstrate this method for in vivo …

Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease

L Sun, CK Macgowan, JG Sled, SJ Yoo, C Manlhiot… - Circulation, 2015 - Am Heart Assoc
Background— Fetal hypoxia has been implicated in the abnormal brain development seen
in newborns with congenital heart disease (CHD). New magnetic resonance imaging …

Maze training in mice induces MRI-detectable brain shape changes specific to the type of learning

…, PW Frankland, RM Henkelman, SA Josselyn, JG Sled - Neuroimage, 2011 - Elsevier
Multiple recent human imaging studies have suggested that the structure of the brain can
change with learning. To investigate the mechanism behind such structural plasticity, we …

Dimensions of the human sclera: thickness measurement and regional changes with axial length

…, I Tertinegg, A Eilaghi, S Portnoy, JG Sled… - Experimental eye …, 2010 - Elsevier
Scleral thickness, especially near the region of the optic nerve head (ONH), is a potential
factor of interest in the development of glaucomatous optic neuropathy. Our goal was to …

Three-dimensional cerebral vasculature of the CBA mouse brain: a magnetic resonance imaging and micro computed tomography study

A Dorr, JG Sled, N Kabani - Neuroimage, 2007 - Elsevier
Studies of mouse cerebral vasculature to date have focused on the circle of Willis without
examining the morphological distribution of blood vessels through the rest of the brain. Since …

Quantitative interpretation of magnetization transfer in spoiled gradient echo MRI sequences

JG Sled, GB Pike - Journal of Magnetic Resonance, 2000 - Elsevier
A method for analyzing general pulsed magnetization transfer (MT) experiments in which off-resonance
saturation pulses are interleaved with on-resonance excitation pulses is …