Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs
used daily in oncology include clinical TNM stage, objective response and left ventricular …

Hypoxia was identified as a microenvironmental component of solid tumours over 60 years
ago and was immediately recognised as a potential barrier to therapy through the reliance of …

Targeted therapeutics have challenged how imaging techniques assess tumour response to
treatment because many new agents are thought to cause cytostasis rather than cytotoxicity…

Radiomics refers to the extraction of mineable data from medical imaging and has been
applied within oncology to improve diagnosis, prognostication, and clinical decision support, …

About 100 early-phase clinical trials and investigator-led studies of targeted antivascular
therapies—both anti-angiogenic and vascular-targeting agents—have reported data derived …

This article reviews the application of dynamic contrast-enhanced magnetic resonance
imaging in both clinical studies and early-phase trials of angiogenesis inhibitors. Emphasis is …

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is now frequently
used in early clinical trial assessment of antiangiogenic and vascular disrupting compounds. …

… JPB O'Connor is supported by a Cancer Research UK Clinician Scientist Fellowship (C19221/A15267).
JPB O'Connor, GJM Parker, and A. Jackson are supported by a Cancer …

Over the last few decades there has been considerable research into quantifying the
cerebral microvasculature with imaging, for use in studies of the human brain and various …

Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …