Brain tumor imaging in clinical trials

JW Henson, S Ulmer, GJ Harris - American Journal of …, 2008 - Am Soc Neuroradiology
There are substantial challenges in the radiologic evaluation of tumor size during clinical trials,
and it is important for neuroradiologists to have a firm understanding of these issues. This …

MRI in treatment of adult gliomas

JW Henson, P Gaviani, RG Gonzalez - The lancet oncology, 2005 - thelancet.com
Diffuse astrocytomas of the adult cerebral hemispheres are unique among tumours in
human beings in the extent to which their imaging features are related to histopathological …

Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: a randomized clinical trial

…, A Silvani, KL Fink, GH Barnett, JJ Zhu, JW Henson… - Jama, 2015 - jamanetwork.com
Importance Glioblastoma is the most devastating primary malignancy of the central nervous
system in adults. Most patients die within 1 to 2 years of diagnosis. Tumor-treating fields (…

CDKN2/p16 or RB Alterations Occur in the Majority of Glioblastomas and Are Inversely Correlated

K Ueki, Y Ono, JW Henson, JT Efird, A Von Deimling… - Cancer research, 1996 - AACR
p16 is involved in a cell cycle regulatory cascade that includes cyclin-dependent kinase 4 (cdk4),
cyclin D1, and pRb (retinoblastoma). Alterations of each of these components have …

[HTML][HTML] Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2–positive breast cancer

…, AD Van den Abbeele, JW Henson… - Journal of clinical …, 2008 - ncbi.nlm.nih.gov
Purpose One third of women with advanced human epidermal growth factor receptor 2 (HER-2)–positive
breast cancer develop brain metastases; a subset progress in the CNS despite …

Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: confounding …

MH Lev, Y Ozsunar, JW Henson… - American Journal …, 2004 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: The MR imaging characteristics of oligodendrogliomas and
astrocytomas on spin-echo (SE), echo-planar relative cerebral blood volume (rCBV) maps, …

Spinal dural enhancement on magnetic resonance imaging associated with spontaneous intracranial hypotension: report of three cases and review of the literature

NN Moayeri, JW Henson, PW Schaefer… - Journal of …, 1998 - thejns.org
✓ This report offers a description of typical changes seen on gadolinium-enhanced
magnetic resonance (MR) imaging of the entire spine that indicate spontaneous intracranial …

The retinoblastoma gene is involved in malignant progression of astrocytomas

JW Henson, BL Schnitker, KM Correa… - Annals of Neurology …, 1994 - Wiley Online Library
Loss of chromosome 13q occurs in up to 50% of human astrocytomas, suggesting the presence
of an astrocytoma tumor suppressor gene on that chromosome. To determine whether …

Structural and functional brain asymmetries in human situs inversus totalis

…, BS Ticho, AM Goldstein, N Makris, JW Henson - Neurology, 1999 - AAN Enterprises
Objective: To determine whether individuals with situs inversus totalis (SI), a condition in
which there is a mirror-image reversal of asymmetric visceral organs, have alterations in brain …

Survival in patients with brain metastases from breast cancer: the importance of HER‐2 status

…, L Schapira, J Younger, JW Henson - … Journal of the …, 2008 - Wiley Online Library
BACKGROUND Brain metastases (BM) are the most common intracranial tumors in adults.
To the authors' knowledge, established prognostic factors for survival after the diagnosis of …