Problem drug use and dependence are neurobehavioral disorders of complex origin. Although
environmental factors contribute to drug abuse and addiction, genetic factors also play a …

Fatty acid amide hydrolase (FAAH) inactivates the endogenous cannabinoid (endocannabinoid)
anandamide and related lipid transmitters in vivo . A single nucleotide polymorphism (…

A neurologic rating scale (NRS) has been developed for clinical assessment of MS patients.
The scale has been tested on 250 MS patients. Assignment of the NRS score is based on …

UBP43 (USP18) is a protease that removes the ubiquitin-like modifier ISG15 from conjugated
proteins. Here we present the first report of dysregulation of protein ISG15 modification by …

We conducted an 18‐month, placebo‐controlled, double‐blind study to evaluate cladribine
in the treatment of 52 patients with relpaasing‐remitting multiple sclerosis. Patients received …

Background Obesity is a worldwide epidemic, and severe obesity is a risk factor for many
diseases, including diabetes, heart disease, stroke, and some cancers. Endocannabinoid …

Immune system responsiveness results from numerous factors, including endogenous
cannabinoid signaling in immunocytes termed the “immunocannabinoid” system. This system can …

A genetic variation in fatty acid amide hydrolase (FAAH), C385A (P129T), has been previously
associated with risk for problem street drug use. FAAH is a mammalian enzyme that …

The islands of Calleja (IC) in the rat are composed of seven small groups of granule cells in
the polymorph layer of the olfactory tubercle and one large group, the insula magna, which …

The human fatty acid amide hydrolase (FAAH) missense mutation c.385 C→A, which results
in conversion of a conserved proline residue to threonine (P129T), has been associated …