Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats

AV Kalueff, KA Lehtimaki, A Ylinen, J Honkaniemi… - Neuroscience …, 2004 - Elsevier
Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in
epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally (400ng…

Haloperidol in the Acute Treatment of Migraine: A Randomized, Double‐Blind, Placebo‐Controlled Study: CME

J Honkaniemi, S Liimatainen… - … : The Journal of …, 2006 - Wiley Online Library
Objective.—To assess the efficacy and safety of IV haloperidol in treatment of acute migraine
headache in a double‐blind, randomized, placebo‐controlled study design. Background.—…

Thymidine kinase 2 mutations in autosomal recessive progressive external ophthalmoplegia with multiple mitochondrial DNA deletions

…, R Pöyhönen, M Korpela, J Honkaniemi… - Human molecular …, 2012 - academic.oup.com
Autosomal-inherited progressive external ophthalmoplegia (PEO) is an adult-onset disease
characterized by the accumulation of multiple mitochondrial DNA (mtDNA) deletions in post-…

Localization of the glucocorticoid receptor in testis and accessory sexual organs of male rat

R Schultz, J Isola, M Parvinen, J Honkaniemi… - Molecular and cellular …, 1993 - Elsevier
Localization of glucocorticoid receptor-like immunoreactivity (GR-LI) was studied in adult rat
testis, epididymis, ejaculatory duct, seminal vesicle and prostate by light and electron …

Expression of carbonic anhydrases II, IV, VII, VIII and XII in rat brain after kainic acid induced status epilepticus

P Halmi, S Parkkila, J Honkaniemi - Neurochemistry international, 2006 - Elsevier
Carbonic anhydrases (CAs) are important enzymes in the central nervous system (CNS),
where they participate in regulating cerebrospinal fluid (CSF) secretion, blood–brain barrier …

Delayed MR imaging changes in acute disseminated encephalomyelitis

J Honkaniemi, P Dastidar, V Kähärä… - American journal of …, 2001 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: White matter lesions on MR images obtained from patients
with acute disseminated encephalomyelitis (ADEM) have been reported to appear shortly …

Colocalization of peptide and glucocorticoid receptor immunoreactivities in rat central amygdaloid nucleus

J Honkaniemi, M Pelto-Huikko, L Rechardt, J Isola… - …, 1992 - karger.com
The central amygdaloid nucleus (ACe) is part of the amygdaloid complex that participates in
adrenocorticotrophin secretion, stress-related reactions and behavioral functions. The ACe …

Global ischemia induces apoptosis-associated genes in hippocampus

J Honkaniemi, SM Massa, M Breckinridge… - Molecular brain …, 1996 - Elsevier
Using in situ hybridization, Northern blotting and RT-PCR we studied the post-ischemic
expression of bcl-2, bcl-x, bax and ICE. One day following 5 min or 10 min of global ischemia bcl-…

Prolonged expression of zinc finger immediate‐early gene mRNAs and decreased protein synthesis following kainic acid induced seizures

J Honkaniemi, FR Sharp - European journal of neuroscience, 1999 - Wiley Online Library
In the present study in situ hybridization was used to study the effect of kainic acid induced
seizures on the expression of the zinc finger immediate‐early genes (IEGs) NGFI‐A, NGFI‐B, …

Purkinje cell vulnerability to mild traumatic brain injury

…, FR SHARP, LH PITTS, J HONKANIEMI… - Journal of …, 1996 - liebertpub.com
In this study we examined the cerebellar response to mild traumatic brain injury by assessing
microglial activation and Purkinje cell loss. Activated microglia were identified using the …