Charged particle beams are ideal for treating skull base and cervical spine tumors: dose can
be focused in the target, while achieving significant sparing of the brain, brain stem, cervical …

Purpose : Following a thorough Phase I II study, we evaluated by a Phase III trial high versus
conventional dose external beam irradiation as mono-therapy for patients with Stage T3–T4 …

The authors evaluated a series of 145 consecutive patients with metastases from uveal
melanoma, after proton beam irradiation, to assess the effect of early diagnosis and treatment for …

Conventional chondrosarcoma (CSA) of the skull base is an uncommon neoplasm that can
resemble chordoma, and indeed it is misdiagnosed frequently as such. This has important …

Purpose: To investigate the feasibility and value of positron emission tomography and computed
tomography (PET/CT) for treatment verification after proton radiotherapy. Methods and …

Objective Atypical and malignant meningiomas are at high risk for local failure. The role of
radiation therapy (RT) and dose levels required to improve tumor control are poorly defined. …

PURPOSE: Local control of osteosarcoma in patients for whom a resection with satisfactory
margins is not achieved can be difficult. This study evaluated the efficacy of radiotherapy (RT…

Object. After conventional doses of 55 to 65 Gy of fractionated irradiation, glioblastoma
multiforme (GBM) usually recurs at its original location. This institutional phase II study was …

✓ Sixty-eight patients with chordoma or low-grade chondrosarcoma at the base of the skull
received fractionated high-dose postoperative radiation delivered with a 160-MeV proton …

Background Melanoma of the eye is the only potentially fatal ocular malignancy in adults.
Until radiation therapy gained wide acceptance in the 1980s, enucleation was the standard …