A theoretical model of blood–brain exchange is developed and a procedure is derived that
can be used for graphing multiple-time tissue uptake data and determining whether a …

The transport of α-aminoisobutyric acid (AIB), N-methyl-AIB (MeAIB), and
diethylenetriaminepentaacetic acid (DTPA) from blood to brain was measured over different …

Background and Purpose—The early ischemic lesions demonstrated by diffusion-weighted
imaging (DWI) are potentially reversible. The purposes of this study were to determine …

The production of cerebrospinal fluid and the transport of 24 Na from the blood to the
cerebrospinal fluid were studied simultaneously in normal and choroid plexectomized rhesus …

LEVIN, VICTOR A., JOSEPH D. FENSTERMACHER, AND CLIFFORD S. PATLAK. Sucrose
and z'nsulin space measurements of cerebral cortex in four mammalian species. Am-J. …

The blood‐to‐brain transfer rate constant (K i ) of Gd‐DTPA was determined in MRI studies
of a rat model of transient cerebral ischemia. The longitudinal relaxation rate, R 1 , was …

Background and Purpose—Genetically engineered mice are used to study the role of single
genes in cerebral ischemia, but inherent, strain-dependent differences in neuronal …

Vasculature in and around the cerebral tumor exhibits a wide range of permeabilities, from
normal capillaries with essentially no blood-brain barrier (BBB) leakage to a tumor …

From the literature, there appears to be inadequate evidence supporting the clinical use of
intraarterial infusions as a method of drug administration. This problem has been evaluated …

The transport of material between blood and tissue within the central nervous system (CNS)
is different than that within most other organs. In contrast to systemic capillaries, the …