A major hindrance to evaluating nematode populations for anthelmintic resistance, as well
as for screening existing drugs, new compounds, or bioactive plant extracts for anthelmintic …

Individual specimens of Anisakis, Pseudoterranova, and Contracaecum collected from marine
mammals inhabiting northern Pacific waters were used for comparative diagnostic and …

Two major human diseases caused by filariid nematodes are onchocerciasis, or river
blindness, and lymphatic filariasis, which can lead to elephantiasis. The drugs ivermectin, …

Lymphatic filariasis is caused by filarial nematode parasites, including Brugia malayi. Adult
worms live in the lymphatic system and cause a strong immune reaction that leads to the …

A serine protease and a serine protease inhibitor were purified from infective larvae of the
parasitic nematode Anisakis simplex. The serine protease was found to be trypsin-like and …

Papain family cysteine proteases are key factors in the pathogenesis of cancer invasion,
arthritis, osteoporosis, and microbial infections. Targeting this enzyme family is therefore one …

The last half-century has provided all of the (few) drugs currently used to treat human
helminthiases. Concern regarding the long-term utility of these drugs, given how readily resistance …

Serine proteases are one of the biologically most important and widely distributed families
of enzymes. Isolation of serine protease genes from organisms of widely diverged …

Cryptosporidiosis, caused by the protozoan parasite Cryptosporidium parvum , can stunt
infant growth and can be lethal in immunocompromised individuals. The most widely used …

Chagas disease affects an estimated 300,000 individuals in the United States. Diagnosis in
the chronic phase requires positive results from two different IgG serological tests. Three …