Glioblastoma multiforme (GBM), a WHO grade IV malignant glioma, is the most common
and lethal primary brain tumor in adults; few treatments are available. Median survival rates …

In highly vascular malignant glioma, glioma cells themselves may express angiogenic
factors and induce angiogenesis. Recent studies have shown that novel angiogenic factors, …

Background and Purpose— The cause of intracranial bleeding in moyamoya disease
patients is still unknown. To identify factors that contribute to bleeding, we assessed the …

Apoptosis plays an important role in delayed neuronal cell death after cerebral ischemia.
Activation of Akt/protein kinase B has been recently reported to prevent apoptosis in several …

OBJECTIVE: The prevention of rebleeding is one of the most important issues in the successful
treatment of moyamoya disease with hemorrhagic onset. However, the natural course of …

Purpose: Glioblastoma represents the malignant brain tumor that is most refractory to treatment
and in which the identification of molecular target(s) is urgently required. We investigated …

Object. Glioblastoma multiforme (GBM) remains incurable by conventional treatments,
although some patients experience long-term survival. A younger age, a higher Karnofsky …

High-grade (World Health Organization grades II and III) meningiomas grow aggressively
and recur frequently, resulting in a poor prognosis. Assessment of tumor malignancy before …

BACKGROUND AND PURPOSE: The best time for surgery after embolization of meningiomas
remains unclear. We used the tumor-softening effect of embolization to determine this time…

✓ Two cases of moyamoya disease associated with repeated intraventricular hemorrhage are
reported. The origin of bleeding was thought to be a distal aneurysm of the choroidal artery…