Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo …

RJ Laham, FW Sellke, ER Edelman, JD Pearlman… - Circulation, 1999 - Am Heart Assoc
Background—Angiogenesis is a promising treatment strategy for patients who are not candidates
for standard revascularization, because it promotes the growth of new blood vessels in …

Magnetic resonance mapping demonstrates benefits of VEGF–induced myocardial angiogenesis

JD Pearlman, MG Hibberd, ML Chuang, K Harada… - Nature medicine, 1995 - nature.com
Coronary occlusive disease is the leading cause of death in industrial nations and affects
one in four adults. Although heart attacks are caused by occlusion of a coronary artery, some …

Impact of mouse strain differences in innate hindlimb collateral vasculature

…, T Ziegelhoeffer, U Brandt, JD Pearlman… - … , and vascular biology, 2006 - Am Heart Assoc
Objective— To assess the importance of genetic background for collateral artery development.
Methods and Results— C57BL/6, BALB/c and 129S2/Sv mice were studied after femoral …

VEGF administration in chronic myocardial ischemia in pigs

…, R J. Laham, A Stamler, JD Pearlman… - Cardiovascular …, 1998 - academic.oup.com
Objective: Previous investigations have shown the effectiveness of sustained intra- or
extravascular administration of vascular endothelial growth factor (VEGF) in chronic myocardial …

Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results

…, RJ Laham, ER Edelman, JD Pearlman… - The Annals of thoracic …, 1998 - Elsevier
Background. Patients not amenable to complete myocardial revascularization by conventional
methods present a difficult clinical problem. Here we present the early results and …

Intracoronary basic fibroblast growth factor (FGF-2) in patients with severe ischemic heart disease: results of a phase I open-label dose escalation study

…, ME Leimbach, JE Udelson, JD Pearlman… - Journal of the American …, 2000 - jacc.org
OBJECTIVES Evaluate the safety, tolerability and preliminary efficacy of intracoronary (IC)
basic fibroblast growth factor (bFGF, FGF-2). BACKGROUND FGF-2 is a heparin-binding …

Detection of exercise-induced ischemia by changes in B-type natriuretic peptides

RS Foote, JD Pearlman, AH Siegel, KTJ Yeo - Journal of the American …, 2004 - jacc.org
Objectives : The purpose of this study was to examine the effect of exercise-induced
ischemia on levels of B-type natriuretic peptide (BNP) and its inactive N-terminal fragment (NT-pro-…

Excretory phase CT urography for opacification of the urinary collecting system.

…, RD Ernst, JD Pearlman - … American journal of …, 1998 - Am Roentgen Ray Soc
The purpose of our study was threefold: to evaluate the ability of excretory phase CT urography
to opacify the urinary collecting system by comparing opacification seen on CT with the …

Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia

…, M Post, D Novicki, FW Sellke, JD Pearlman… - … of Pharmacology and …, 2000 - ASPET
Therapeutic angiogenesis is a novel approach to the treatment of myocardial ischemia based
on the use of proangiogenic growth factors to induce the growth of new blood vessels to …

Efficacy of intracoronary versus intravenous FGF-2 in a pig model of chronic myocardial ischemia

K Sato, RJ Laham, JD Pearlman, D Novicki… - The Annals of thoracic …, 2000 - Elsevier
Background. Therapeutic angiogenesis in ischemic myocardium has been shown to be a
feasible and effective strategy to improve regional blood flow and myocardial function. However…