… k Existing literature demonstrates that innovation and investment in new technology are
most likely to occur when rewards are tied to marginal improvements in environmental impacts …

Purpose: The purpose of this statement is to review the literature regarding mitochondrial
disease and to provide recommendations for optimal diagnosis and treatment. This statement …

Fabry disease is an X-linked metabolic storage disorder due to the deficiency of lysosomal α-galactosidase
A, and the subsequent accumulation of glycosphingolipids, primarily …

This article describes a system for the evolution and coevolution of virtual creatures that
compete in physically simulated three-dimensional worlds. Pairs of individuals enter one-on-one …

This paper describes a novel system for creating virtual creatures that move and behave in
simulated three-dimensional physical worlds. The morphologies of creatures and the neural …

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective
treatment. We report the results of a moderate-scale sequencing study aimed at increasing the …

This paper describes how evolutionary techniques of variation and selection can be used to
create complex simulated structures, textures, and motions for use in computer graphics and …

Balanced chromosomal abnormalities (BCAs) represent a relatively untapped reservoir of
single-gene disruptions in neurodevelopmental disorders (NDDs). We sequenced BCAs in …

Fabry disease (FD) is an X-linked lysosomal storage disease caused by alpha-galactosidase
A deficiency. The Fabry Registry is a global clinical effort to collect longitudinal data on FD. …

As global efforts to protect ecosystems expand, the socioeconomic impact of protected
areas on neighboring human communities continues to be a source of intense debate. The …