In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise
to generate mutations in virtually every protein-coding gene of the mouse genome in a …

Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic skin
disorder associated with skin barrier dysfunction. The lesional skin of AD exhibits T helper …

Although new drugs have recently been developed within the field of ophthalmology, the
eye's various defense mechanisms make it difficult to achieve an effective concentration of …

The adipocyte-derived hormone adiponectin has been shown to play important roles in the
regulation of energy homeostasis and insulin sensitivity. In this study, we analyzed globular …

… were fabricated by SM, KI, YS and K. Yamamura. The conditions for this experiment were
set up by KT, YN and MY Experimental planning was carried out by HM, TI and K. Yamauchi. …

Two cell lines have been established from insulinomas obtained by targeted expression of
the simian virus 40 T antigen gene in transgenic mice. These cell lines, designated MIN6 and …

… Japan has a growing presence throughout the Asian region, and Walter Hatch and Kozo
Yamamura find that many standard Japanese business practices have been transplanted. …

Interleukin 6 (IL-6) has been suggested to be involved in the pathogenesis of polyclonal and
monoclonal plasma cell abnormalities. To address this possibility, transgenic mice carrying …

The normal plasma protein serum amyloid P component (SAP) binds to fibrils in all types of
amyloid deposits, and contributes to the pathogenesis of amyloidosis. In order to intervene in …

The hallmark of type 2 diabetes, the most common metabolic disorder, is a defect in insulin–stimulated
glucose transport in peripheral tissues. Although a role for phosphoinositide–3–…