Ghrelin, an endogenous ligand for the GH secretagogue receptor, was isolated from rat
stomach and is involved in a novel system for regulating GH release. Although previous studies …

Using a specific radioimmunoassay for human brain natriuretic peptide (hBNP) with a
monoclonal antibody, we have investigated its synthesis, secretion, and clearance in comparison …

… . Chehab, FF, Mounzih, K., Lu, R. & Lim, ME Early onset of reproductive function in normal
female mice treated … Hosoda, K. et al. Development of radioimmunoassay for human leptin. …

… with inhibitory constant (K i )values of 1.4 and 1.8 nmol/l, respectively, whereas it shows low
affinities for human Y2 (K>10,000 nmol/l), Y4 (K i >620 nmol/l), Y5 receptors (K >6,000 nmol/l…

Ghrelin is a recently identified endogenous ligand for the GH secretagogue receptor and is
involved in a novel system for regulating GH release. However, little is known about its GH-…

TNM staging is no doubt the most critical prognostic factors, representing tumor (T)/lymph
node metastasis (N)/distant metastasis (M) in gastric cancer. Lymph node ratio-based N …

Hirschsprung’s disease (HSCR) is characterized by an absence of enteric ganglia in the
distal colon and a failure of innervation in the gastrointestinal tract. We recently mapped a …

To elucidate the ligand-receptor relationship of the natriuretic peptide system, which
comprises at least three endogenous ligands, atrial natriuretic peptide (ANP), brain natriuretic …

Endothelins act on two subtypes of G protein-coupled receptors, termed endothelin-A and
endothelin-B receptors. We report a targeted disruption of the mouse endothelin-B receptor (…

Defects in the gene encoding the endothelin-B receptor produce aganglionic megacolon
and pigmentary disorders in mice and humans. We report that a targeted disruption of the …