Background Cardiac disease is a leading cause of stroke in children, yet limited data support
the current stroke prevention and treatment recommendations. A multidisciplinary panel of …

Background Our objective was to characterize the frequency, early impact, and risk factors
for neurological manifestations in hospitalized children with acute severe acute respiratory …

Extracorporeal membrane oxygenation is extracorporeal life support for life-threatening
cardiopulmonary failure. Since its introduction, the use of extracorporeal membrane oxygenation …

In the midst of concerns for potential neurodevelopmental effects after surgical anesthesia,
there is a growing awareness that children who require sedation during critical illness are …

Silent cerebral infarcts (SCIs) are associated with cognitive impairment in sickle cell anemia
(SCA). SCI risk factors include low hemoglobin and elevated systolic blood pressure; …

… Kristin Guilliams collected and interpreted data. Dustin Ragan collected, processed, and
interpreted data and created figures. Michael Binkley analyzed and interpreted data and …

Blood transfusions are the mainstay of stroke prevention in pediatric sickle cell anemia (SCA),
but the physiology conferring this benefit is unclear. Cerebral blood flow (CBF) and …

Individuals with sickle cell disease (SCD) experience cognitive deficits; however, it remains
unclear whether medical treatments for SCD improve cognition. Given that executive abilities …

Chronic transfusion therapy (CTT) prevents stroke in selected patients with sickle cell
anemia (SCA). We have shown that CTT mitigates signatures of cerebral metabolic stress, …

Background Large-vessel vasculopathy (LVV) increases stroke risk in pediatric sickle cell
disease beyond the baseline elevated stroke risk in this vulnerable population. The …