[HTML][HTML] BANK regulates BCR‐induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor

K Yokoyama, I Su, T Tezuka, T Yasuda… - The EMBO …, 2002 - embopress.org
B‐cell activation mediated through the antigen receptor is dependent on activation of protein
tyrosine kinases (PTKs) such as Lyn and Syk and subsequent phosphorylation of various …

Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth

…, T Suzuki, T Nakamura, K Yokoyama… - … and cellular biology, 2007 - Am Soc Microbiol
The stability of mRNA influences the abundance of cellular transcripts and proteins.
Deadenylases play critical roles in mRNA turnover and thus are important for the regulation of …

[HTML][HTML] Humoral response against host-mimetic homologous epitopes of Mycobacterium avium subsp. paratuberculosis in Japanese multiple sclerosis patients

D Cossu, K Yokoyama, LA Sechi, S Otsubo… - Scientific reports, 2016 - nature.com
Several works have demonstrated the existence of a link between Mycobacterium avium
subsp. paratuberculosis (MAP) and MS in Italy. In this study, we analyzed the serology of MAP …

Safety and efficacy of rozanolixizumab in patients with generalised myasthenia gravis (MycarinG): a randomised, double-blind, placebo-controlled, adaptive phase 3 …

…, T Hatano, K Oikoshi, K Yokoyama… - The Lancet …, 2023 - thelancet.com
Background Generalised myasthenia gravis is a chronic, unpredictable, and debilitating
autoimmune disease. New treatments for this disease are needed because conventional …

Autoimmune targets of heart and skeletal muscles in myasthenia gravis

…, M Motomura, S Matsubara, K Yokoyama… - Archives of …, 2009 - jamanetwork.com
Objective To investigate the clinical, histological, and immunological features of patients
with myasthenia gravis (MG) who also developed myocarditis and/or myositis. Design …

[HTML][HTML] Differences of behavioral and psychological symptoms of dementia in disease severity in four major dementias

…, T Matsumoto, T Mori, T Kashibayashi, K Yokoyama… - PloS one, 2016 - journals.plos.org
Background/Aims Behavioral and psychological symptoms of dementia (BPSDs) negatively
impact the prognosis of dementia patients and increase caregiver distress. The aims of this …

Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis

…, M Kawai, S Kikuchi, K Nomura, K Yokoyama… - Neurobiology of …, 2005 - Elsevier
To clarify the molecular mechanisms underlying multiple sclerosis (MS)-promoting autoimmune
process, we have investigated a comprehensive gene expression profile of T cell and …

[HTML][HTML] Apathy/depression, but not subjective fatigue, is related with cognitive dysfunction in patients with multiple sclerosis

…, T Yamamura, F Yoshii, J Kira, S Nakane, K Yokoyama… - BMC neurology, 2014 - Springer
Background Cognitive impairment could affect quality of life for patients with multiple sclerosis
(MS), and cognitive function may be correlated with several factors such as depression …

[HTML][HTML] Plasmablasts as migratory IgG-producing cells in the pathogenesis of neuromyelitis optica

…, T Matsuoka, M Nakamura, H Kishida, K Yokoyama… - PloS one, 2013 - journals.plos.org
Neuromyelitis optica (NMO) is an inflammatory disease characterized by recurrent attacks of
optic neuritis and myelitis. It is generally accepted that autoantibodies against aquaporin 4 …

Diffusional kurtosis imaging of normal-appearing white matter in multiple sclerosis: preliminary clinical experience

M Yoshida, M Hori, K Yokoyama, I Fukunaga… - Japanese journal of …, 2013 - Springer
Purpose We evaluated diffusional changes in normal-appearing white matter (NAWM) regions
remote from multiple sclerosis (MS) plaques by using diffusional kurtosis imaging (DKI) to …