Three‐pool model of white matter

JL Lancaster, T Andrews, LJ Hardies… - Journal of Magnetic …, 2003 - Wiley Online Library
Purpose To investigate the use of a three‐pool relaxation model to measure myelin,
myelinated‐axon, and mixed water‐pool fractions in white matter (WM) during myelination. Materials …

Brain correlates of stuttering and syllable production

…, PT Fox, JC Ingham, J Xiong, F Zamarripa, LJ Hardies… - 2004 - ASHA
This article reports a gender replication study of the PT Fox et al.(2000) performance
correlation analysis of neural systems that distinguish between normal and stuttered speech in …

Narrowing critical regions and determining penetrance for selected 18q‐phenotypes

…, EM Carter, J Li, LJ Hardies… - American Journal of …, 2009 - Wiley Online Library
One of our primary goals is to help families who have a child with an 18q deletion anticipate
medical issues in order to optimize their child's medical care. To this end we have narrowed …

Recurrent interstitial deletions of proximal 18q: a new syndrome involving expressive speech delay

…, CM Cody, LJ Hardies… - American Journal of …, 2007 - Wiley Online Library
Most deletions of the long arm of chromosome 18 involve some part of the most distal 30 Mb.
We have identified five individuals with cytogenetically diagnosed interstitial deletions that …

Growth hormone benefits children with 18q deletions

…, M Semrud‐Clikeman, LJ Hardies… - American Journal of …, 2005 - Wiley Online Library
Most individuals with constitutional deletions of chromosome 18q have developmental
delays, dysmyelination of the brain, and growth failure due to growth hormone deficiency. We …

Myelination in children with partial deletions of chromosome 18q

…, JD Cody, T Andrews, LJ Hardies… - American journal …, 2005 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: We compared myelin levels in white matter (WM) in typically
developing children with those of children with partial deletions of chromosome 18q (18q−…

Molecular characterization of a patient with central nervous system dysmyelination and cryptic unbalanced translocation between chromosomes 4q and 18q

…, DE Hale, JL Lancaster, LJ Hardies… - American Journal of …, 2003 - Wiley Online Library
We report on a 12‐year‐old boy who presented with delayed development and CNS
dysmyelination. Genetic studies showed a normal 46,XY karyotype by routine cytogenetic analysis, …

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

…, SA Harrison, R Belfort‐Aguilar, LJ Hardies… - …, 2009 - Wiley Online Library
Pioglitazone treatment improves insulin resistance (IR), glucose metabolism, hepatic steatosis,
and necroinflammation in patients with nonalcoholic steatohepatitis (NASH). Because …

Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus

…, R Baig, S Suraamornkul, LJ Hardies… - The Journal of …, 2010 - academic.oup.com
Context: Lipotoxicity (increased tissue fat content) has been implicated in the development
of muscle insulin resistance and type 2 diabetes mellitus (T2DM). Objective: The aim was to …

Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects

A Gastaldelli, K Cusi, M Pettiti, J Hardies, Y Miyazaki… - Gastroenterology, 2007 - Elsevier
Background & Aims: Abdominal fat accumulation (visceral/hepatic) has been associated
with hepatic insulin resistance (IR) in obesity and type 2 diabetes (T2DM). We examined the …