Cancer therapy has developed around the concept of killing, or stopping the growth of, the
cancer cells. Molecularly targeted therapy is the modern expression of this paradigm. …

Background Rindopepimut (also known as CDX-110), a vaccine targeting the EGFR deletion
mutation EGFRvIII, consists of an EGFRvIII-specific peptide conjugated to keyhole limpet …

Overview. The Quality Standards Subcommittee seeks to develop scientifically sound,
clinically relevant practice parameters for the practice of neurology. Practice parameters are …

Standard treatment for neoplastic meningitis requires frequent intrathecal (IT) injections of
chemotherapy and is only modestly effective. DepoCyt is a sustained-release formulation of …

BACKGROUND Detection of malignant cells on cytologic examination of the cerebrospinal
fluid (CSF) is the diagnostic gold standard for leptomeningeal carcinomatosis. The absence …

Glioblastoma (GB) is one of the most lethal forms of cancer, with an invasive growth pattern
that requires the use of adjuvant therapies, including chemotherapy and radiation, to prolong …

Background The epidermal growth factor receptor variant III deletion mutation, EGFRvIII, is
expressed in ∼30% of primary glioblastoma and linked to poor long-term survival. …

… Peak methotrexate concentrations ranged from 3.7 to 55 micromol/L (mean, 17.1 micromol/L)
in CSF and 178 to 1,700 micromol/L (mean, 779 micromol/L) in serum. Cytotoxic CSF and …

Gene expression profiling has proven useful in subclassification and outcome prognostication
for human glial brain tumors. The analysis of biological significance of the hundreds or …

Background and Purpose—Anecdotal reports suggest that a loss of distinction between gray
(GM) and white matter (WM) as adjudged by CT scan predicts poor outcome in comatose …