Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell
types and as a secreted form in the plasma of vertebrates. Mutant mice for gelsolin as well …

The transcription factor Sox2 is active in neural stem cells, and Sox2`knockdown' mice show
defects in neural stem/progenitor cells in the hippocampus and eye, and possibly some …

We have examined the mechanism of signal transduction by the hemidesmosomal integrin
alpha 6 beta 4, a laminin receptor involved in morphogenesis and tumor progression. …

Podosomes are punctate adhesion structures first described in osteoclasts and next found in
src-transformed cells of mesenchymal origin. Podosomes were never observed in cultured …

To examine the function of the alpha 6 beta 4 integrin we have determined its ligand-binding
ability and overexpressed two potentially dominant negative mutant beta 4 subunits, …

Secondary lymphoid organ stromal cells comprise different subsets whose origins remain
unknown. Herein, we exploit a genetic lineage-tracing approach to show that splenic …

Since coronavirus disease 2019 (COVID-19) outbreak, neurologic manifestations have been
increasingly reported including encephalopathy; however, the underlying pathophysiology …

… experiments, high numbers of podosomes similar to those exhibited by rat 804G cells,
were found in primary mouse keratinocytes showing features similar to those described (Spinardi …

The integrin β 4 has a long cytodomain necessary for hemidesmosome formation. A yeast
two-hybrid screen using β 4 cytodomain uncovered a protein called p27 BBP that represents a …

Efficient and reliable detection of single base substitutions has proven increasingly important
in biomedical research. A variety of methods have been proposed among which Single …