Although significant improvements have been made in the outcomes of children with cancer,
the pace of improvement has slowed in recent years as the limits of therapy intensification …

The neurotrophin family of growth factors supports survival and differentiation of neurons in
the developing vertebrate nervous system by binding activating receptor tyrosine kinases, …

The wide variety of clinical manifestations of the genetic syndrome neurofibromatosis type 1
(NF1) are driven by overactivation of the RAS pathway. Mitogen-activated protein kinase …

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by increased
incidence of benign and malignant tumors of neural crest origin. Mutations that activate …

The mechanisms underlying neuronal ischemic preconditioning, a phenomenon in which brief
episodes of ischemia protect against the lethal effects of subsequent periods of prolonged …

Nerve growth factor induces differentiation and survival of rat PC12 pheochromocytoma
cells. The activation of the erk cascade has been implicated in transducing the multitude of …

… Klesse, MD, PhD, 8 Sarah Leary, MD, 23 Javad Nazarian, PhD, 24 Marcel Kool, PhD, 25
Pieter Wesseling, MD, 26 Marina Ryzhova, MD, 27 Olga Zheludkova, MD, 28 Andrey V …

Neurofibromatosis type 1 (NF1) clinical care is on the cusp of a transformative shift. With the
success of recent clinical trials using MEK inhibitors, an increasing number of NF1 patients …

Nerve growth factor (NGF) is a required differentiation and survival factor for sympathetic and
a majority of neural crest-derived sensory neurons in the developing vertebrate peripheral …

We have analyzed signaling pathways involved in neurotrophic factor (NTF)-induced
upregulation of nociceptive properties, specifically vanilloid receptor type 1 (VR1), by adult rat …