To make adaptive decisions, animals must evaluate the costs and benefits of available options.
The nascent field of neuroeconomics has set itself the ambitious goal of understanding …

Psychologists and economists have long appreciated the contribution of reward history and
expectation to decision-making. Yet we know little about how specific histories of choice and …

Neural responses are typically characterized by computing the mean firing rate, but response
variability can exist across trials. Many studies have examined the effect of a stimulus on …

Deep brain stimulation is a promising treatment for neuropsychiatric conditions such as
major depression. It could be optimized by identifying neural biomarkers that trigger therapy …

Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in
randomized trials raises questions regarding anatomical targeting. We implanted multi-site …

The equilibrium phenomenon of matching behavior traditionally has been studied in stationary
environments. Here we attempt to uncover the local mechanism of choice that gives rise …

Mendelian disorders and monogenic traits result from combinations of variants in 1 or a few
genes that have a large effect on the propensity for developing a certain disease or …

Background Converging evidence suggests that immune-mediated dysfunction plays an
important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic studies …

Cardiovascular (CV)-and lifestyle-associated risk factors (RFs) are increasingly recognized
as important for Alzheimer’s disease (AD) pathogenesis. Beyond the ε4 allele of …

Background Clinical, pathological and genetic overlap between sporadic frontotemporal
dementia (FTD), Alzheimer's disease (AD) and Parkinson's disease (PD) has been suggested; …