Background and purpose There is still no curative treatment for multiple sclerosis ( MS ), but
during the last 20 years eight different disease‐modifying compounds have been approved …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. The primary
pathological target in multiple sclerosis is myelin. Most MS patients follow a relapsing–…

Background Multiple sclerosis is an inflammatory demyelinating disease of the central nervous
system and is the most common cause of neurologic disability in young adults. Despite …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system that causes motor, sensory, and cognitive deficits. The present study characterized …

BACKGROUND AND PURPOSE: Cortical lesions constitute a substantial part of the total
lesion load in multiple sclerosis (MS) brain. They have been related to neuropsychological …

Objective Four different patterns of demyelination have been described in active demyelinating
lesions of multiple sclerosis (MS) patients that were biopsied shortly after disease onset. …

Memory impairment is especially prominent within the spectrum of cognitive deficits in multiple
sclerosis (MS), and a crucial role for hippocampal pathology may therefore be expected …

Background: Substantial grey matter (GM) demyelination occurs in both the cerebral cortex
and spinal cord in multiple sclerosis (MS). GM demyelination also occurs in the cerebellar …

Objective Inflammatory and demyelinating activity of activated resident macrophages (microglia)
and recruited blood‐borne macrophages are considered crucial in multiple sclerosis (…

Postmortem MRI-guided tissue sampling significantly enhances the yield of MS lesions in
autopsy material, but so far it is unknown whether abnormalities concur with blood–brain …