This review describes cancer stem cells, a topic of considerable biologic and clinical interest
in oncology.

Protein kinases and phosphatases play pivotal roles in regulating and coordinating aspects
of metabolism, gene expression, cell growth, cell motility, cell differentiation, and cell division…

CCP4mg is a molecular-graphics program that is designed to give rapid access to both
straightforward and complex static and dynamic representations of macromolecular structures. It …

Major international projects are underway that are aimed at creating a comprehensive catalogue
of all the genes responsible for the initiation and progression of cancer 1 , 2 , 3 , 4 , 5 , 6 …

Despite recent insights into melanoma genetics, systematic surveys for driver mutations are
challenged by an abundance of passenger mutations caused by carcinogenic UV light …

We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

We have identified a cell type in 7-day-old rat optic nerve that differentiates into a fibrous
astrocyte if cultured in the presence of fetal calf serum and into an oligodendrocyte if cultured in …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …

For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we
describe the genomic landscape of 496 PTCs. We observed a low frequency of somatic …