The initial mechanical tissue disruption of spinal cord injury (SCI) is followed by a period of
secondary injury that increases the size of the lesion. The secondary injury has long been …

Current treatments for acute spinal cord injury are based on animal models of human spinal
cord injury (SCI). These models have shown that the initial traumatic injury to cord tissue is …

The secondary cascade of cell death that follows central nervous system (CNS) injury or
ischemia has long been considered a target for neuroprotective agents aimed at sparing tissue …

Activity-dependent modulation of synaptic efficacy in the brain contributes to neural circuit
development and experience-dependent plasticity. Although glia are affected by activity and …

Behavioral assessment after spinal cord contusion has long focused on open field locomotion
using modifications of a rating scale developed by Tarlov and Klinger (1954). However, on…

… Recently, a more sensitive locomotor rating scale, the Basso, Beattie, and Bresnahan scale
(BBB), was developed but had not been tested on rats with severe SCI complete transection. …

… Koman and JB Beattie for excellent technical assistance and to an anonymous reviewer
for suggesting the use of CC1. Supported by grants NS32000, NS 10165, N5 31193 and NS …

The Multicenter Animal Spinal Cord Injury Study (MASCIS) adopted a modified 21-point
open field locomotor scale developed by Basso, Beattie, and Bresnahan (BBB) at Ohio State …

Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 -…

The neurotrophin receptor p75 is induced by various injuries to the nervous system, but its
role after injury has remained unclear. Here, we report that p75 is required for the death of …