In vivo magnetic resonance spectroscopy (MRS), functional magnetic resonance imaging (fMRI),
and diffusion-tensor imaging (DTI) have recently opened new possibilities for …

Background Frontotemporal dementia is a highly heritable neurodegenerative disorder. In
about a third of patients, the disease is caused by autosomal dominant genetic mutations …

The tau gene has been found to be the locus of dementia with rigidity linked to chromosome
17. Exonic and intronic mutations have been described in a number of families. Here we …

BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) offers a unique window on
the connectivity changes, extending beyond the basal ganglia, which accompany the …

Purpose: To determine the values of iron accumulation in the basal ganglia of healthy
volunteers of different ages with R2* and raw signal intensity measurements from T1-weighted …

Clinical diagnosis of olivopontocerebellar atrophy (OPCA) must be confirmed by radiologic
demonstration of atrophy in an appropriate distribution. OPCA may be associated with …

Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes.
In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed …

BACKGROUND AND OBJECTIVE: Biomarkers to monitor neurological dysfunction in
autosomal dominant inherited spinocerebellar ataxias (SCA) are lacking. We therefore aimed to …

Objective: To identify cognitive and MRI features important for the clinical diagnosis of
corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP); these diseases …

Spinocerebellar ataxias are dominantly inherited disorders that are associated with
progressive brain degeneration, mainly affecting the cerebellum and brainstem. As part of the …